Objectives To identify the frequency of CYP2C9* 1,* 2 and* 3 alleles and the genotype of
CYP2C9 gene in the Tamilian population. Methods The study was conducted on 135 …

Background: CYP2C19 is responsible for the metabolism of a wide variety of medications
this enzyme encoded by highly polymorphic gen. Aim: the aim of this study was to determine …

Purpose Despite the advances in the pharmacological treatment of epilepsy,
pharmacoresistance still remains challenging. Understanding of the pharmacogenetic …

Polymorphisms in CYP2C8 and CYP3A5 genes have implications for responses elicited by
the ingestion of some xenobiotics, the metabolism of which are mediated by these enzymes …

BACKGROUND: The aim of this study is to determine the polymorphism of the CYP2C19
gene in the Lebanese population living in Colombia due to the lack of information and the …

Background: Cytochrome P450 2C19 (CYP2C19) is a polymorphically expressed enzyme
that shows marked interindividual and interethnic variation. CYP2C19* 2 and CYP2C19* 3 …

BACKGROUND: CYP3A5 enzymes belong to the phase I Group of drug-metabolizing
enzymes, which are involved in the metabolism of 50% of the drugs. Participants with …

Background This research aims to study the association of genetic polymorphism in genes
coding for CYP2C9 and CYP2C19 in phenytoin-induced dose-related toxicity and to assess …

Diverse distributions of pharmacogenetically relevant variants of highly polymorphic
CYP2C9, CYP2D6 and CYPOR genes are responsible for some varied drug responses …

CYP2C19 is expressed polymorphically with about 21 variant alleles. Genotype-phenotype
association studies of CYP2C19 have shown marked deviations, suggesting the presence of …