Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the
failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole …

Antimicrobial resistance (AMR) is a complex threat to human health and, to date, it
represents a hot topic in drug discovery. The use of non-antibiotic molecules to block …

NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to
fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also …

Since the discovery of the first antibiotics, bacteria have acquired a variety of resistance
mechanisms, with efflux pump (EP) being the most prominent mechanism for intracellular …

Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While
molecular analyses have identified efflux pump expression as an essential mechanism …

Objective Efflux pumps are transmembrane proteins associated with bacterial resistance
mechanisms. Bacteria use these proteins to actively transport antibiotics to the extracellular …

Background and objectives Staphylococcus aureus is an opportunistic pathogen that causes
wide range of nosocomial and community-acquired infections which have spread worldwide …

The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …

The World Health Organization indicated that antibiotic resistance is one of the greatest
threats to health, food security, and development in the world. Drug resistance efflux pumps …

Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide
spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance …