The immune microenvironment and expression of PD‐L1, PD‐1, PRAME and MHC I in salivary duct carcinoma

B Xu, AA Jungbluth, D Frosina, B Alzumaili… - …, 2019 - Wiley Online Library
Aims Salivary duct carcinoma (SDC) is an aggressive salivary malignancy that results in
high mortality rates and is often resistant to chemotherapy. Anti‐programmed death‐1 (PD …

Programmed death ligand‐1 expression is associated with poor disease free survival in salivary gland carcinomas

T Mukaigawa, R Hayashi, K Hashimoto… - Journal of surgical …, 2016 - Wiley Online Library
Background and Objectives The immune checkpoint ligand programmed death ligand‐1
(PD‐L1) is expressed in various carcinomas and allows carcinoma cells to elude the …

The expression of programed death ligand‐1 could be related with unfavorable prognosis in salivary duct carcinoma

F Sato, J Akiba, A Kawahara, Y Naito… - Journal of Oral …, 2018 - Wiley Online Library
Background Salivary duct carcinoma (SDC) is a rare tumor occurring in the salivary gland.
SDC is a highly aggressive tumor and its prognosis is extremely poor. Effective treatments in …

Overexpression of PD-L2 is associated with shorter relapse-free survival in patients with malignant salivary gland tumors

H Chang, JS Kim, YJ Choi, JG Cho, JS Woo… - OncoTargets and …, 2017 - Taylor & Francis
Objectives PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an
important role in tumor evasion. This study aimed to investigate expression patterns of …

Prognostic impact of PD-L1 expression in malignant salivary gland tumors as assessed by established scoring criteria: tumor proportion score (TPS), combined …

HM Witte, N Gebauer, D Lappöhn, VG Umathum… - Cancers, 2020 - mdpi.com
Background: Malignant neoplasms of the salivary glands are rare, and therapeutic options
are limited. Results from recently published studies indicate a possible use for checkpoint …

Simultaneous expression of PD-1 and PD-L1 in peripheral and central immune cells and tumor cells in the benign and malignant salivary gland tumors …

S Gerdabi, F Asadian, R Kiani, B Khademi… - Head and Neck …, 2023 - Springer
Background To investigate the differential expression of PD-1 and PD-L1 in salivary gland
tumors (SGTs, malignant and benign subtypes) and determine their association with the …

Incidence and prognostic significance of PD-L1 expression in high-grade salivary gland carcinoma

Q Fang, Y Wu, W Du, X Zhang, D Chen - Frontiers in Oncology, 2021 - frontiersin.org
Objective PD-L1 is one of the predictors of immunotherapy efficacy. Our goal was to analyze
its expression and prognostic significance in high-grade salivary gland carcinoma (SGC) …

PD-L1 expression in malignant salivary gland tumors

K Harada, T Ferdous, Y Ueyama - BMC cancer, 2018 - Springer
Abstract Background Programmed death-1 ligand-1 (PD-L1) an important cancer biomarker
that can suppress the immune system and its high expression is often reported to be related …

Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas

T Nakano, K Takizawa, A Uezato, K Taguchi, S Toh… - Oral oncology, 2019 - Elsevier
Objectives The aim of the present study was to investigate the molecular basis for the use of
immune checkpoint inhibitors to treat salivary gland carcinomas (SGC). Materials and …

PD-L1 expression by immunohistochemistry in salivary duct carcinoma

A Hamza, D Roberts, S Su, RS Weber, D Bell… - Annals of diagnostic …, 2019 - Elsevier
Background Immune checkpoint inhibitors play an increasing role in oncologic care. PD-L1
expression is associated with survival and predicts response to PD-1 or PD-L1 inhibitors in a …