The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, a neglected
tropical disease that affects around 8 million people worldwide. Chagas disease can be …

Investigations into intracellular replication and differentiation of Trypanosoma cruzi within
the mammalian host have been restricted by limitations in our ability to detect parasitized …

Detection of genetic exchange has been a limiting factor to deepen the knowledge on the
mechanisms by which Trypanosoma cruzi is able to generate progeny and genetic diversity …

The ability of the Chagas disease agent Trypanosoma cruzi to resist extended in vivo
exposure to highly effective trypanocidal compounds prompted us to explore the potential for …

Coxiella burnetii, the etiological agent of Q fever, is an obligate intracellular bacterium that
resides within acidified vacuoles with secondary lysosomal characteristics. Infective stages …

As Trypanosoma cruzi, the etiological agent of Chagas disease, multiplies in the cytoplasm
of nucleated host cells, infection with this parasite is highly likely to affect host cells. We …

A major contributor to treatment failure in Chagas disease, caused by infection with the
protozoan parasite Trypanosoma cruzi, is that current treatment regimens do not address the …

Since the discovery of Trypanosoma cruzi as the parasite that causes Chagas disease,
nearly a century ago, the details of the organism's life cycle have fascinated scientists. T …

Chronic Trypanosoma cruzi infections are typically lifelong, with small numbers of parasites
surviving in restricted tissue sites, which include the gastrointestinal tract. There is …

Naturally occurring DNA variants of the single-cell-derived Y-02 stock of Trypanosoma cruzi
were discovered during a routine assay of the stock. Three DNA variant types were isolated …