Introduction This study was designed to compare the inhibitory effect of inhaled volatile
anesthetic agents on in situ sympathetic neural versus nonneural regulation of vascular …

Background Administration of general anesthetics to patients with chronic hypertension
often causes hemodynamic instability that has been attributed in part to a poorly understood …

Background The purpose of this study was to compare the effects of isoflurane on
membrane and intracellular mechanisms that regulate vascular smooth muscle (VSM) …

Background Vascular endothelium plays an important role in the regulation of vascular tone.
Volatile anesthetics have been shown to attenuate endothelium-mediated relaxation in …

Background A primary source of calcium (Ca2+) necessary for excitation contraction in
vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force …

General anesthetics threaten cardiovascular stability by causing changes in cardiac
function, vascular reactivity, and cardiovascular reflexes and significantly alter distribution of …

Background It is believed that isoflurane decreases blood pressure predominantly by
decreasing systemic vascular resistance with modest myocardial depression. Nevertheless …

Background The precise mechanisms behind the direct inhibitory action of sevoflurane on
vascular smooth muscle have not been fully elucidated. Methods Endothelium-denuded …

Volatile anesthetics act at a number of sites to alter cardiovascular function and the
response of the cardiovascular system to barostatic reflexes. We examined the effects of …

Background The direct action of sevoflurane on systemic resistance arteries is not fully
understood. Methods Isometric force was recorded in isolated rat small mesenteric arteries …