Volatile anesthetics vasodilate in part by direct action on vascular smooth muscle. Isoflurane-
induced relaxation of portal vein smooth muscle involves alteration of membrane ionic …

Background Volatile anesthetic actions on intracellular Ca2+ stores (ie., sarcoplasmic
reticulum [SR]) of vascular smooth muscle have not been fully elucidated. Methods Using …

Background Although halothane and isoflurane inhibit receptor agonist-induced smooth
muscle contraction by inhibiting Ca2+ influx via the L-type voltage-dependent Ca2+ …

Background Whether volatile anesthetics produce changes in vascular resistance and blood
flow because of direct effects on vascular tissue is unclear. Direct vasoconstricting and …

Background A primary source of calcium (Ca2+) necessary for excitation contraction in
vascular smooth muscle (VSM) is influx via voltage-dependent Ca2+ channels. Thus, force …

Background Isoflurane has been shown to directly inhibit vascular reactivity. However, less
information is available regarding its underlying mechanisms in systemic resistance arteries …

Isoflurane is a potent systemic vasodilator. Because isoflurane vasodilation is clinically
significant, we sought to explore whether decreases in systemic vascular resistance caused …

Background. Sevoflurane reduces blood pressure, the regulation of which requires an intact
sympathetic neurotransmission. This study was designed to evaluate the effect of …

Background Systemic vascular resistance (the ratio of mean aortic pressure [AP] and mean
aortic blood flow [AQ]) does not completely describe left ventricular (LV) afterload because of …

The effects of antiarrhythmic doses of lidocaine on efferent sympathetic outflow or
sympathetic responses to autonomic stimuli in humans are unknown. In the present study …