Mitochondrial genetics has become an emerging area of research in the field of modern
therapeutics. Mitochondrial genome is the source of 13 polypeptides which are components …

Background: Mitochondria are intracellular organelles involved in energy production, which
play important roles in metabolism. Consequently, mutation in mitochondrial DNA may have …

Mitochondria are membrane-bound cellular organelles of high relevance responsible for the
chemical energy production used in most of the biochemical reactions of cells. Mitochondria …

Given the essential functions of these organelles in cell homeostasis, their involvement in
incurable diseases and their potential in biotechnological applications, genetic …

Purpose Mitochondria are competent for DNA uptake in vitro, a mechanism which may
support delivery of therapeutic DNA to complement organelle DNA mutations. We document …

The approval of mRNA-containing lipid nanoparticles (LNPs) for use in a vaccine against the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the clinical utility of …

The field of mitochondrial research is currently among the fastest growing disciplines in
biomedicine. Approximately 12,000 articles on mitochondria have been published since the …

Mitochondria are attractive organelles that have the potential to contribute greatly to medical
therapy. This organnelle is responsible for a variety of essential functions including ATP …

Mitochondrial gene therapy seems to be a valuable and promising strategy to treat
mitochondrial disorders. The use of a therapeutic vector based on mitochondrial DNA, along …

All discussions on the intracellular delivery of DNA are based on a seemingly evident
assumption that the key task is to bring the intact DNA into the cell cytoplasmic compartment …