In vivo determination of intra‐myocellular lipids in human muscle by means of localized 1H‐MR‐spectroscopy

C Boesch, J Slotboom, H Hoppeler… - Magnetic resonance in …, 1997 - Wiley Online Library
Intra‐myocellular lipids (IMCL) are stored in droplets in the cytoplasm of muscle cells and
are an energy storage form readily accessed during long‐term exercise. 1H‐MR …

Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and 1H-MR spectroscopy

H Howald, C Boesch, R Kreis… - Journal of Applied …, 2002 - journals.physiology.org
Three different methods to determine intramyocellular lipid (IMCL) contents in human
skeletal muscle have been compared. 1H-magnetic resonance spectroscopy (MRS) was …

Observation of Intramyocellular Lipids by1H‐Magnetic Resonance Spectroscopy

C Boesch, R Kreis - Annals of the New York Academy of …, 2000 - Wiley Online Library
Magnetic resonance (MR) methods are increasingly being used to investigate the
physiology of human muscle. Although MR imaging (MRI) reveals the morphology of …

Observation of intramyocellular lipids by means of 1H magnetic resonance spectroscopy

C Boesch, J Décombaz, J Slotboom… - Proceedings of the …, 1999 - cambridge.org
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) are being
increasingly used for investigations of human muscle physiology. While MRI reveals the …

Intramyocellular Lipid Quantification: Repeatability with 1H MR Spectroscopy1

M Torriani, BJ Thomas, EF Halpern, ME Jensen… - Radiology, 2005 - pubs.rsna.org
PURPOSE: To prospectively determine the repeatability and variability of tibialis anterior
intramyocellular lipid (IMCL) quantifications performed by using 1.5-T hydrogen 1 (1H) …

Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS)

K Brechtel, AM Niess, J Machann, K Rett… - Hormone and …, 2001 - thieme-connect.com
Trained subjects are characterized by enhanced levels of lipolytic and mitochondrial
enzymes, and, hence, a higher reliance on fat oxidation, especially during aerobic …

Regional differences in intramyocellular lipids in humans observed by in vivo 1H-MR spectroscopic imaging

JH Hwang, JW Pan, S Heydari… - Journal of Applied …, 2001 - journals.physiology.org
Regional differences in the content of intramyocellular lipids (IMCL), extramyocellular lipids,
and total creatine (TCr) were quantified in soleus (S), tibialis posterior (TP), and tibialis …

Role of proton MR for the study of muscle lipid metabolism

C Boesch, J Machann, P Vermathen… - NMR in Biomedicine …, 2006 - Wiley Online Library
Abstract 1H‐MR spectroscopy (MRS) of intramyocellular lipids (IMCL) became particularly
important when it was recognized that IMCL levels are related to insulin sensitivity. While …

Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: A dynamic 1H‐MRS study

K Brechtel, DB Dahl, J Machann… - … in Medicine: An …, 2001 - Wiley Online Library
The influence of a short‐term elevation of free fatty acids (FFAs) on intramyocellular lipids
(IMCL) under hyperinsulinemic conditions was monitored in five healthy male subjects in the …

Intramyocellular lipids and insulin resistance

J Machann, H Häring, F Schick… - Diabetes, Obesity and …, 2004 - Wiley Online Library
Lipids are stored not only in adipocytes but also 'ectopically'in tissues such as muscle, liver,
beta cells and others. From a metabolic perspective, intramyocellular lipids (IMCLs) have …