Germinal centers in lymphoid tissue are the sites of generation of memory B cells
undergoing isotype switching and somatic mutation in their Ig genes. Their formation cannot …

Germinal centers (GCs) are the sites where B cells undergo affinity maturation. The
regulation of cellular output from the GC is not well understood. Here, we show that from the …

Germinal centers (GCs) are specialized microenvironments where antigen-activated B cells
undergo proliferation, immunoglobulin (Ig) class switch recombination, somatic …

Follicular dendritic cells (FDCs) were identified decades ago by their ability to retain immune
complexes and more recent findings indicate that they are a source of B cell attractants and …

Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and
high-affinity B cell antigen receptors (BCRs) for pathogen clearance. Increased receptor …

Germinal centers (GCs) are specialized microenvironments formed after infection where
activated B cells can mutate their B‐cell receptors to undergo affinity maturation. A stringent …

Adaptive B cell responses are initiated by B cell receptor–antigen engagement. Despite its
importance, the early stages of B cell interaction with antigen in vivo remain elusive. Using …

Germinal centers (GCs) are dynamic microenvironments that form in the secondary
lymphoid organs and generate somatically mutated high-affinity antibodies necessary to …

Long-lasting Ab responses rely on the germinal center (GC), where B cells bearing high-
affinity Ag receptors are selected from a randomly mutated pool to populate the memory and …

Most adult B cell lymphomas originate from germinal center (GC) B cells, but it is unclear to
what extent B cells in overt lymphoma retain the functional dynamics of GC B cells or are …