Antagonism of the STING pathway via activation of the AIM2 inflammasome by intracellular DNA
L Corrales, SR Woo, JB Williams… - The Journal of …, 2016 - journals.aai.org
Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic
cells via the host STING pathway is a major mechanism leading to spontaneous T cell …
cells via the host STING pathway is a major mechanism leading to spontaneous T cell …
Mechanism and regulation of gasdermin-mediated cell death
The innate immune system senses and responds to pathogens and endogenous damage
through supramolecular protein complexes known as inflammasomes. Cytosolic …
through supramolecular protein complexes known as inflammasomes. Cytosolic …
[HTML][HTML] Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling
H Konno, K Konno, GN Barber - Cell, 2013 - cell.com
Activation of the stimulator of interferon genes (STING) pathway by microbial or self-DNA, as
well as cyclic dinucleotides (CDNs), results in the induction of numerous genes that …
well as cyclic dinucleotides (CDNs), results in the induction of numerous genes that …
[HTML][HTML] Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Z Dai, WC Liu, XY Chen, X Wang, JL Li… - Frontiers in …, 2023 - frontiersin.org
Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …
self-protection mechanisms against stimuli and infections. Hosts can defend against …
YIPF5 is essential for innate immunity to DNA virus and facilitates COPII-dependent STING trafficking
Y Ran, M Xiong, Z Xu, W Luo, S Wang… - The Journal of …, 2019 - journals.aai.org
STING plays central roles in the innate immune response to pathogens that contain DNA.
Sensing cytoplasmic DNA by cyclic GMP-AMP synthase produces cyclic GMP-AMP, which …
Sensing cytoplasmic DNA by cyclic GMP-AMP synthase produces cyclic GMP-AMP, which …
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion
C Zhang, S Ye, J Ni, T Cai, Y Liu, D Huang… - Cell Death & …, 2019 - nature.com
Stimulator of interferon genes (STING), a major adaptor protein in antiviral innate immune
signaling, is considered as one of the most important regulators of antiviral and antitumor …
signaling, is considered as one of the most important regulators of antiviral and antitumor …
STING promotes homeostasis via regulation of cell proliferation and chromosomal stability
Given the integral role of stimulator of interferon genes (STING, TMEM173) in the innate
immune response, its loss or impairment in cancer is thought to primarily affect antitumor …
immune response, its loss or impairment in cancer is thought to primarily affect antitumor …
STING licensing of type I dendritic cells potentiates antitumor immunity
Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-
AMP in response to self or microbial cytosolic DNA as a danger signal. STING is …
AMP in response to self or microbial cytosolic DNA as a danger signal. STING is …
[HTML][HTML] PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation
Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting
the host against DNA pathogen invasion. However, the molecular mechanism underlying …
the host against DNA pathogen invasion. However, the molecular mechanism underlying …
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by
binding to microbial or self DNA in the cytoplasm. Upon binding DNA, cGAS produces …
binding to microbial or self DNA in the cytoplasm. Upon binding DNA, cGAS produces …