Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation

H Hammad, BN Lambrecht - Journal of allergy and clinical immunology, 2006 - Elsevier
Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter and
integrating signals derived from the antigen, its inflammatory context, and the host …

The role of dendritic cells in immune regulation and allergic airway inflammation

JW Upham - Respirology, 2003 - Wiley Online Library
Dendritic cells (DC) are potent antigen presenting cells that display an extraordinary
capacity to present antigen to naïve T‐cells and initiate primary immune responses. In the …

Why are dendritic cells important in allergic diseases of the respiratory tract?

JW Upham, PA Stumbles - Pharmacology & therapeutics, 2003 - Elsevier
Increasing evidence points to the role of antigen-presenting dendritic cells (DC) in regulating
adaptive immune responses. DC are especially sensitive to signals derived from microbes …

Dendritic cells revisited in human allergic rhinitis and asthma

A Froidure, C Shen, C Pilette - Allergy, 2016 - Wiley Online Library
The role of dendritic cells (DC s) in airway allergy has been studied for 15 years; recent data
has highlighted the cross talk with airway epithelial cells and environmental factors …

[PDF][PDF] Biology of lung dendritic cells at the origin of asthma

BN Lambrecht, H Hammad - Immunity, 2009 - cell.com
Dendritic cells (DCs) initiate and maintain adaptive T helper 2 (Th2) cell responses to
inhaled allergens in asthma. Various functions like antigen uptake, migration to the draining …

Airway dendritic cells: Co‐ordinators of immunological homeostasis and immunity in the respiratory tract

PA Stumbles, JW Upham, PG Holt - Apmis, 2003 - Wiley Online Library
The large quantities and complex mixtures of antigens encountered daily at airway mucosal
and alveolar surfaces pose a major challenge to maintenance of immunological …

Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: implications for the pathogenesis of infectious and allergic airway …

A Rate, JW Upham, A Bosco, KL McKenna… - The Journal of …, 2009 - journals.aai.org
Atopic asthma pathogenesis is driven by the combined effects of airway inflammation
generated during responses to viral infections and aeroallergens, and both these pathways …

Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma

H Hammad, BN Lambrecht - Nature Reviews Immunology, 2008 - nature.com
Dendritic cells (DCs) are generally held responsible for initiating and maintaining allergic T
helper 2 (TH2)-cell responses to inhaled allergens in asthma. Although the epithelium was …

Dendritic cells as regulators of the immune response to inhaled allergen: recent findings in animal models of asthma

BN Lambrecht, HC Hoogsteden… - International archives of …, 2001 - karger.com
Antigen-presenting dendritic cells are essential for the recognition and presentation of
allergens to the cells of the immune system. Airway dendritic cells capture allergen in the …

Dendritic cells in allergic airway inflammation

AS Bharadwaj, AK Bewtra… - Canadian Journal of …, 2007 - cdnsciencepub.com
Dendritic cells (DCs) are primary antigen-presenting cells involved in interactions with T
cells leading to the proliferation of TH1 or TH2 cell types. In asthma, predominance of TH2 …