Minoxidil: mechanisms of action on hair growth

AG Messenger, J Rundegren - British journal of dermatology, 2004 - academic.oup.com
We have known for over 30 years that minoxidil stimulates hair growth, yet our
understanding of its mechanism of action on the hair follicle is very limited. In animal studies …

Minoxidil use in dermatology, side effects and recent patents

A Rossi, C Cantisani, L Melis, A Iorio… - Recent patents on …, 2012 - ingentaconnect.com
Minoxidil, a vasodilator medication known for its ability to slow or stop hair loss and promote
hair regrowth, was first introduced, exclusively as an oral drug, to treat high blood pressure …

The effect of topical minoxidil on hair follicular cycles of rats

O Mori, H Uno - The Journal of dermatology, 1990 - Wiley Online Library
To explore an easily accessible and reproducible model for examining the effect of minoxidil
on hair growth, we studied the effect of minoxidil on the natural hair cycles of rats from birth …

Minoxidil sulfate is the active metabolite that stimulates hair follicles

AE Buhl, DJ Waldon, CA Baker, GA Johnson - Journal of Investigative …, 1990 - Elsevier
An important step in understanding minoxidil's mechanism of action on hair follicles was to
determine the drug's active form. We used organ-cultured vibrissa follicles to test whether it …

Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells

Lachgar, Charveron, Gall, Bonafe - British Journal of …, 1998 - Wiley Online Library
The hair follicle dermal papilla which controls hair growth, is characterized in the anagen
phase by a highly developed vascular network. We have demonstrated in a previous study …

Action of topical minoxidil in the bald stump-tailed macaque

H Uno, A Cappas, P Brigham - Journal of the American Academy of …, 1987 - Elsevier
The effect of topical minoxidil (5% and 2% solutions) on hair regrowth was studied in the
frontal bald scalp of 18 adolescent and adult stump-tailed macaques (Macaca arctoides) …

Minoxidil stimulates mouse vibrissae follicles in organ culture

AE Buhl, DJ Waldon, TT Kawabe, JM Holland - Journal of investigative …, 1989 - Elsevier
Minoxidil, a potent vasodilator, stimulates the growth of terminal hair from vellus or
miniaturized follicles in balding scalp. To study minoxidil's action on isolated follicles we …

Topical minoxidil for hair regrowth

EE Vanderveen, CN Ellis, S Kang, P Case… - Journal of the American …, 1984 - Elsevier
Minoxidil, a potent peripheral vasodilator used orally for refractory hypertension, has
produced hypertrichosis. To determine the efficacy and safety of 1% or 5% topical minoxidil …

The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial

RS Berger, JL Fu, KA Smiles, CB Turner… - British Journal of …, 2003 - academic.oup.com
Background Recent studies of antidandruff shampoos or tonics containing antifungal or
antibacterial agents produced effects suggestive of a potential hair growth benefit …

[HTML][HTML] Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of …

A Marubayashi, Y Nakaya, K Fukui, M Li… - Journal of investigative …, 2001 - Elsevier
The mechanism by which minoxidil, an adenosine-triphosphate-sensitive potassium
channel opener, induces hypertrichosis remains to be elucidated. Minoxidil has been …