Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to
crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) …

Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …

Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …

Occupational exposure to crystalline silica (CS) particles leads to silicosis, which is
characterized by chronic inflammation and abnormal tissue repair. Alveolar macrophages …

Long term pulmonary exposure to crystalline silica leads to silicosis that manifests
progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite …

Environmental exposure to crystalline silica (CS) can lead to silicosis. Alveolar
macrophages (AMs) play a crucial role in the pathogenesis of silicosis. Previously, we …

Background Silicosis is an occupational lung disease caused by inhalation of silica dust
characterized by lung inflammation and fibrosis. Previous study showed that Th1 and Th2 …

Chronic exposure to crystalline silica can lead to the development of silicosis, an
irreversible, inflammatory and fibrotic pulmonary disease. Although, previous studies …

Silicosis of pulmonary fibrosis (PF) is related to long-term excessive inhalation of silica. The
activation of fibroblasts into myofibroblasts is the main terminal effect leading to lung fibrosis …

Silicosis is the most common pneumoconiosis globally, with higher prevalence and
incidence in developing countries. To date, there is no effective treatment to halt or reverse …