The cannabinoid (CB) system is widespread in the central nervous system and is crucial for
controlling a range of neurophysiological processes such as pain, appetite, and cognition …

Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a
variety of effects in the human body. They have been studied in cellular and animal models …

The endocannabinoid system has been shown to be associated with neurodegenerative
diseases and dementia. We review the preclinical and clinical data on cannabinoids and …

At the beginning of the 21st century, the therapeutic management of neurodegenerative
disorders remains a major biomedical challenge, particularly given the worldwide ageing of …

Unprecedented developments in cannabinoid research within the past decade include
discovery of a brain (CB1) and peripheral (CB2) receptor; endogenous ligands …

Cannabinoids form a singular family of plant-derived compounds (phytocannabinoids),
endogenous signaling lipids (endocannabinoids), and synthetic derivatives with multiple …

Endocannabinoids act as retrograde messengers that, by inhibiting neurotransmitter release
via presynaptic CB1 cannabinoid receptors, regulate the functionality of many synapses. In …

The endocannabinoid system (ECS) exerts a modulatory effect of important functions such
as neurotransmission, glial activation, oxidative stress, or protein homeostasis …

Cannabinoids comprise three classes of compounds, the active components of marijuana
(Cannabis sativa), as well as endogenous and synthetic derivatives. To date, two distinct …

The G-protein coupled receptors for Δ9-tetrahydrocannabinol, the major psychoactive
principle of marijuana, are known as cannabinoid receptors of type 1 (CB1) and 2 (CB2) and …