Hydroxy pentacyclic triterpene acid, kaempferol, inhibits the human 5-hydroxytryptamine type 3A receptor activity

S Lee, HS Seol, S Eom, J Lee, C Kim, JH Park… - International Journal of …, 2022 - mdpi.com
Monoamine serotonin is a major neurotransmitter that acts on a wide range of central
nervous system and peripheral nervous system functions and is known to have a role in …

Structure−Affinity Relationship Study on N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-Aryl-1-Piperazinealkylamides, a New Class of 5-Hydroxytryptamine7 Receptor …

M Leopoldo, F Berardi, NA Colabufo… - Journal of medicinal …, 2004 - ACS Publications
A series of N-(1, 2, 3, 4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides was
prepared and their affinity for serotonin (5-hydroxytryptamine, 5-HT) 5-HT7, 5-HT1A, and 5 …

Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5-HT3A receptors due to the action of …

R Herbrechter, PM Ziemba, KM Hoffmann… - Frontiers in …, 2015 - frontiersin.org
The traditional Japanese phytomedicine rikkunshito is traditionally used for the treatment of
gastrointestinal motility disorders, cachexia and nausea. These effects indicate 5-HT3 …

ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors

T Riccioni, F Bordi, P Minetti, G Spadoni… - European journal of …, 2011 - Elsevier
HT 6 receptor is one of the most recently cloned serotonin receptors, and it might play
important roles in Alzheimer's disease, depression, and learning and memory disorders …

Activation and modulation of recombinantly expressed serotonin receptor type 3A by terpenes and pungent substances

PM Ziemba, BSP Schreiner, C Flegel… - Biochemical and …, 2015 - Elsevier
Abstract Serotonin receptor type 3 (5-HT 3 receptor) is a ligand-gated ion channel that is
expressed in the central nervous system (CNS) as well as in the peripheral nervous system …

Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT2A Receptor Antagonists

L Ding, S He, W Wu, H Jin, P Zhu, J Zhang, T Wang… - Molecules, 2015 - mdpi.com
5-Hydroxytryptamine type 2A (5-HT2A) receptor is an important target for developing
innovative antipsychotic agents in neuropsychiatric disorder therapies. To search for 5-HT2A …

Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor

F Bai, T Yin, EM Johnstone, C Su, G Varga… - European journal of …, 2004 - Elsevier
The human 5-HT1E receptor gene was cloned more than a decade ago. Little is known
about its function, and there have been no reports of its existence in the genome of small …

Localization of 5-ht5A receptor-like immunoreactivity in the rat brain

KR Oliver, AM Kinsey, A Wainwright… - Brain research, 2000 - Elsevier
5-Hydroxytryptamine exerts modulatory physiological effects on both the central and
peripheral nervous systems by activation of discrete receptor families. 5-ht5A is among the …

Molecular cloning and pharmacological characterization of serotonin 5-HT3A receptor subtype in dog

TN Jensen, J Nielsen, K Frederiksen, B Ebert - European journal of …, 2006 - Elsevier
In order to establish if the canine 5-hydroxytryptamine type 3A (5-HT3A) receptors share the
pharmacological profile with human 5-HT3A receptors, we cloned and performed a …

Development and challenges in the discovery of 5-HT1A and 5-HT7 receptor ligands

D Singh, P Singh, P Srivastava, D Kakkar, M Pathak… - Bioorganic …, 2023 - Elsevier
Abstract Serotonin (5-hydroxytryptamine) is a small molecule that acts both in the central
and peripheral nervous system as a neurotransmitter and a hormone, respectively …