A series of cisplatin-resistant cell lines were used to examine the formation and removal of
platinum-DNA adducts from the overall genome and the formation and removal of cisplatin …

We examined several aspects of platinum-DNA adduct formation and repair in cisplatin-
sensitive and-resistant human ovarian cancer cell lines. The formation of cisplatin …

Two human ovarian tumor cell lines (SK-OV-3 and TR175), established from patients
previously treated with alkylating agents, but not with cisplatin, expressed> 23-fold …

We have examined a panel of 12 unrelated human ovarian cancer cell lines derived from
patients who were either untreated or treated with platinum-based chemotherapy to …

We have examined the relationship between cis-diamminedichloroplatinum (II)(cisplatin)
resistance and replicative bypass in the human ovarian carcinoma cell lines 2008, A2780 …

We have studied several aspects of DNA damage formation and repair in human ovarian
cancer cell lines which have become resistant to cisplatin through continued exposure to the …

A human ovarian cancer cell line, A2780, derived from an untreated ovarian cancer patient
and relatively sensitive to cisplatin was treated by stepwise incubation with cisplatin to …

Acquired resistance to cisplatin has been generated in vitro in two human ovarian
carcinoma cell lines: 41M, established from a previously untreated patient; and CH1, from a …

We have examined the effects of the cis-diammine and 1, 2-diaminocyclohexane (dach)
carrier ligands on cytotoxicity, platinum accumulation and efflux, platinum incorporation into …

Studies were undertaken to investigate acquired resistance to cisplatin in human ovarian
cancer cells. The cell lines A2780 and A2780/CP70 were studied to assess their respective …