L-arginine/nitric oxide pathway is altered in colorectal cancer and can be modulated by novel derivatives from oxicam class of non-steroidal anti-inflammatory drugs

M Krzystek-Korpacka, B Szczęśniak-Sięga, I Szczuka… - Cancers, 2020 - mdpi.com
Simple Summary Nitric oxide and arginine metabolism in colorectal cancer (CRC) holds
potential for therapeutic intervention. We hypothesized that it can be modulated by oxicams …

Esophageal squamous cell carcinoma is accompanied by local and systemic changes in L-arginine/NO pathway

I Bednarz-Misa, P Fortuna, MG Fleszar… - International Journal of …, 2020 - mdpi.com
The L-arginine/NO pathway holds promise as a source of potential therapy target and
biomarker; yet, its status and utility in esophageal squamous cell carcinoma (ESCC) is …

[PDF][PDF] Nitric oxide synthesis modulation-a possible diagnostic and therapeutic target in colorectal cancer

B Brankovic, G Stanojevic, I Stojanovic, A Veljkovic… - J BUON, 2017 - jbuon.com
Purpose: Considering the contradictory literature data about the role of nitric oxide (NO) in
colon carcinogenesis, the purpose of this study was to examine the changes of L-arginine …

Chemoprevention of colon cancer by iNOS-selective inhibitors

NB Janakiram, CV Rao - Onco Therapeutics, 2012 - dl.begellhouse.com
Nitric oxide (NO) is a short-lived pleiotropic regulator and is required for numerous
pathophysiological functions, including macrophage-mediated immunity and cancer. It is a …

Nitric oxide signaling in colon cancer chemoprevention

CV Rao - … Research/Fundamental and Molecular Mechanisms of …, 2004 - Elsevier
Nitric oxide (NO) is a pleiotrophic regulator, pivotal to numerous biological processes,
including vasodilation, neurotransmission, and macrophage-mediated immunity. The highly …

[HTML][HTML] Blockade of IDO-kynurenine-AhR axis ameliorated colitis-associated colon cancer via inhibiting immune tolerance

X Zhang, X Liu, W Zhou, Q Du, M Yang, Y Ding… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Chronic inflammation in colon section is associated with an increased
risk of colorectal cancer (CRC). Proinflammatory cytokines were produced in a tumor …

Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma

P Mandal - Inflammopharmacology, 2018 - Springer
Colorectal cancer (CRC) is the one of the most important diseases throughout the world.
Several aetiological risk factors, viz. sedentary life style, smoking, alcohol intake, less …

Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis

W Wang, J Yang, ML Edin, Y Wang, Y Luo, D Wan… - Cancer research, 2019 - AACR
Colon cancer is the third most common cancer and the second leading cause of cancer-
related death in the United States, emphasizing the need for the discovery of new cellular …

Arginine metabolism and its potential in treatment of colorectal cancer

T Du, J Han - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Colorectal cancer is the leading cause of death from cancer globally. The current treatment
protocol still heavily relies on early detection and surgery. The molecular mechanisms …

Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

CV Rao, BS Reddy, VE Steele, CX Wang, X Liu… - Molecular cancer …, 2006 - AACR
Nitric oxide–releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising
chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable …