L-arginine/nitric oxide pathway is altered in colorectal cancer and can be modulated by novel derivatives from oxicam class of non-steroidal anti-inflammatory drugs
M Krzystek-Korpacka, B Szczęśniak-Sięga, I Szczuka… - Cancers, 2020 - mdpi.com
Simple Summary Nitric oxide and arginine metabolism in colorectal cancer (CRC) holds
potential for therapeutic intervention. We hypothesized that it can be modulated by oxicams …
potential for therapeutic intervention. We hypothesized that it can be modulated by oxicams …
Esophageal squamous cell carcinoma is accompanied by local and systemic changes in L-arginine/NO pathway
The L-arginine/NO pathway holds promise as a source of potential therapy target and
biomarker; yet, its status and utility in esophageal squamous cell carcinoma (ESCC) is …
biomarker; yet, its status and utility in esophageal squamous cell carcinoma (ESCC) is …
[PDF][PDF] Nitric oxide synthesis modulation-a possible diagnostic and therapeutic target in colorectal cancer
B Brankovic, G Stanojevic, I Stojanovic, A Veljkovic… - J BUON, 2017 - jbuon.com
Purpose: Considering the contradictory literature data about the role of nitric oxide (NO) in
colon carcinogenesis, the purpose of this study was to examine the changes of L-arginine …
colon carcinogenesis, the purpose of this study was to examine the changes of L-arginine …
Chemoprevention of colon cancer by iNOS-selective inhibitors
NB Janakiram, CV Rao - Onco Therapeutics, 2012 - dl.begellhouse.com
Nitric oxide (NO) is a short-lived pleiotropic regulator and is required for numerous
pathophysiological functions, including macrophage-mediated immunity and cancer. It is a …
pathophysiological functions, including macrophage-mediated immunity and cancer. It is a …
Nitric oxide signaling in colon cancer chemoprevention
CV Rao - … Research/Fundamental and Molecular Mechanisms of …, 2004 - Elsevier
Nitric oxide (NO) is a pleiotrophic regulator, pivotal to numerous biological processes,
including vasodilation, neurotransmission, and macrophage-mediated immunity. The highly …
including vasodilation, neurotransmission, and macrophage-mediated immunity. The highly …
[HTML][HTML] Blockade of IDO-kynurenine-AhR axis ameliorated colitis-associated colon cancer via inhibiting immune tolerance
Background & Aims Chronic inflammation in colon section is associated with an increased
risk of colorectal cancer (CRC). Proinflammatory cytokines were produced in a tumor …
risk of colorectal cancer (CRC). Proinflammatory cytokines were produced in a tumor …
Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma
P Mandal - Inflammopharmacology, 2018 - Springer
Colorectal cancer (CRC) is the one of the most important diseases throughout the world.
Several aetiological risk factors, viz. sedentary life style, smoking, alcohol intake, less …
Several aetiological risk factors, viz. sedentary life style, smoking, alcohol intake, less …
Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis
Colon cancer is the third most common cancer and the second leading cause of cancer-
related death in the United States, emphasizing the need for the discovery of new cellular …
related death in the United States, emphasizing the need for the discovery of new cellular …
Arginine metabolism and its potential in treatment of colorectal cancer
T Du, J Han - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Colorectal cancer is the leading cause of death from cancer globally. The current treatment
protocol still heavily relies on early detection and surgery. The molecular mechanisms …
protocol still heavily relies on early detection and surgery. The molecular mechanisms …
Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets
CV Rao, BS Reddy, VE Steele, CX Wang, X Liu… - Molecular cancer …, 2006 - AACR
Nitric oxide–releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising
chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable …
chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable …