Nitric oxide (NO) is involved in various physiological functions and its role in tumorigenesis
has been well studied. A large majority of human and experimental tumors appear to …

Reactive oxygen species (ROS) are produced by mitochondria during metabolism. In
physiological states, the production of ROS and their elimination by antioxidants are kept in …

Metabolic reprogramming is a hallmark of cancer, which is still far from being fully
understood in colorectal cancer. In order to characterize the metabolic changes in colorectal …

The expression of inducible nitric oxide synthase (iNOS) is markedly elevated in rat colon
cancers induced by azoxymethane (AOM). In addition, iNOS can be detected in most …

Colorectal cancer (CRC) has become the fourth leading cause of cancer‐related death in
the worldwide. It is urgent to find more effective therapeutic strategies for it. Reactive oxygen …

Nitric oxide (NO) is a signaling molecule that plays important roles in diverse biological
processes and thus its dysregulation is involved in the pathogenesis of various disorders. In …

Significance: Gastrointestinal (GI) cancer taken together constitutes one of the most common
cancers worldwide with a broad range of etiological mechanisms. In this review, we have …

L-arginine/nitric oxide pathway in Crohn's disease (CD) and ulcerative colitis (UC) is poorly
investigated. The aim of current study is to quantify pathway serum metabolites in 52 CD (40 …

Abstract AKR1B1 and AKR1B10, members of the aldo-keto reductase family of enzymes that
participate in the polyol pathway of aldehyde metabolism, are aberrantly expressed in colon …

Inflammation is well recognized to be associated with tumorigenesis, cancer progression
and tumor metabolism of colorectal cancer (CRC). 2-Deoxy-D-glucose (2-DG), a glycolytic …