We previously showed that NCX 4040 inhibits in vitro and in vivo tumor growth and induces
apoptosis in human colon cancer cell lines. On the basis of these results, NCX 4040 …

It is strongly established by numerous studies that oxidative stress-induced inflammation is
one of the major causative agents in a variety of cancers. Various factors such as bacterial …

It is widely accepted that many cancers express features of inflammation, driven by both
microenvironmental cells and factors, and the intrinsic production of inflammation …

Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …

Reactive Oxygen Species or “ROS” encompass several molecules derived from oxygen that
can oxidize other molecules and subsequently transition rapidly between species. The key …

benzothiazines have ameliorative effects through inhibition of COX-2 mediated STAT-3
pathways at G-protein couple receptor site. As per this scenario, we recently prepared and …

Purpose: Evidence suggests that the majority of colorectal carcinomas arise from adenomas,
and l-arginine suppresses colorectal tumorigenesis. We suppose that l-arginine may inhibit …

The use of nitric oxide-donating nonsteroidal anti-inflammat... : Current Opinion in
Gastroenterology The use of nitric oxide-donating nonsteroidal anti-inflammatory drugs in the …

Colorectal cancer (CRC) is the third most common diagnosed cancer of which risk factors
include unhealthy diet, smoking, and chronic inflammation. Weakening the inflammatory …

A group of nitric oxide (NO)-releasing derivatives of oleanolic acid (OA)(5–13) were
designed, synthesized and biologically evaluated for their anti-colon cancer activity. It was …