Colorectal carcinogenesis (CRC) is the most important health concerns throughout the
World as the tumour cells rapidly spread and abruptly grow in colon and rectum to further …

Abstract Cyclooxygenase (COX)‐2 has been suggested to play an important role in colon
carcinogenesis. We found that the COX‐2 selective inhibitor, nimesulide, reduces …

FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands
of FXR. FXR activation has recently been reported to inhibit intestinal inflammation and …

Colon cancer is a major cause of cancer-related deaths worldwide. Adjuvant chemotherapy
significantly reduces mortality in stage III colon cancer; however, it is only marginally …

Background Diclofenac is one of the oldest anti-inflammatory drugs in use. In addition to its
inhibition of cyclooxygenases (COX), diclofenac potently inhibits phospholipase A2 (PLA2) …

There is a pressing need for molecular targets and biomarkers in gastric cancer (GC). We
aimed at identifying aberrations in L-arginine metabolism with therapeutic and diagnostic …

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Oxidative
phosphorylation (OXPHOS) has attracted a considerable attention in CRC. It is of great …

The role of reactive nitrogen species (RNS) in colon carcinogenesis is multifactorial and
affects diverse processes, such as proliferation, apoptosis, differentiation, tumorigenesis …

Endogenous metabolites are a class of molecules playing diverse and significant roles in
many metabolic pathways for disease. Honokiol (HNK), an active poly-phenolic compound …

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the
role of NO is decided by its concentration present in physiological environments. NO either …