Background It has been widely accepted that angiogenesis plays fundamental roles in
colorectal cancer development, and therapeutic targeting of this pathway has achieved …

This article was designed by using a network pharmacological approach to reveal the
therapeutic targets and molecular mechanisms of oxyresveratrol (Oxyres) treating colorectal …

Simple Summary Colorectal cancer is a disease associated with a high mortality rate. During
the tumorigenic process, several factors and signaling molecules produced by tumor cells …

Therapeutic benefits offered by common chemotherapy drugs, such as oxaliplatin, are
limited due to the development of resistance, which contributes to treatment failure and …

Colorectal cancer (CRC) is the one of the leading causes of cancer-related deaths in the
world. CRC is responsible for more than 600,000 deaths annually and incidence rates are …

The action of L-arginine is mainly dependent on its end-product, nitric oxide (NO). The L-
arginine/NO pathway has been confirmed to play an important role in tumor development …

Background Colorectal cancers (CRC) are associated with perturbations in cellular amino
acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic …

Simple Summary Colorectal cancer (CRC) is very common throughout the world. Despite an
improved outcome with the current treatment regimen, a huge number of patients relapse …

Deleterious effects of environmental exposures may contribute to the rising incidence of
early-onset colorectal cancer (eoCRC). We assessed the metabolomic differences between …

Aberrant activation of nuclear factor kappa B (NF-κB) has been linked with the pathogenesis
of several proinflammatory diseases including number of cancers and inflammatory bowel …