Late-stage colorectal cancer is resistant to current treatments. Understanding the biological
processes responsible for the development and progression of colorectal cancer could aid …

The serrated pathway to colorectal tumor formation involves oncogenic mutations in the
BRAF gene, which are sufficient for initiation of hyperplastic growth but not for tumor …

Colorectal cancer (CRC) is the third most common cancer worldwide and the second
leading cause of cancer death in the United States. Cytotoxic therapies cause significant …

Alterations in cellular metabolism, such as dysregulation in glycolysis, lipid metabolism, and
glutaminolysis in response to hypoxic and low-nutrient conditions within the tumor …

Introduction 3. Metabolism and physiological effects of polyamines and nitric oxide on
normal and cancerous colonic epithelial cells 3.1. Metabolism of L-arginine in the polyamine …

Non-steroidal anti-inflammatory drugs (NSAIDs) are emerging as novel chemopreventive
agents against a variety of cancers owing to their capability in blocking the tumor …

L-Arginine itself and its metabolite-nitric oxide play great roles in intestinal physiology.
However, the molecular mechanism underlying nitric oxide pathway regulating L-Arginine …

Background It is well established that hypercholesterolemia increases the risk of
atherosclerosis, especially because it reduces the availability of nitric oxide (NO). However …

Initiation of various cancers has been observed to be regulated via a prolonged
inflammatory state in the tissues. However, molecular role of such a localized inflammation …

Cancer cells exhibit a wide range of metabolic phenotypes, ranging from strict aerobic
glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic …