IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice
AI Thaker, MS Rao, KS Bishnupuri, TA Kerr, L Foster… - Gastroenterology, 2013 - Elsevier
Background & Aims Indoleamine 2, 3 dioxygenase-1 (IDO1) catabolizes tryptophan along
the kynurenine pathway. Although IDO1 is expressed in inflamed and neoplastic epithelial …
the kynurenine pathway. Although IDO1 is expressed in inflamed and neoplastic epithelial …
[PDF][PDF] Recent advances and future directions in etiopathogenesis and mechanisms of reactive oxygen species in cancer treatment
Cancer remains a significant global health burden, affecting both developed and developing
nations, despite advancements in cancer diagnosis, treatment, and prevention. Annually …
nations, despite advancements in cancer diagnosis, treatment, and prevention. Annually …
Epigenetic and metabolic reprogramming in inflammatory bowel diseases: diagnostic and prognostic biomarkers in colorectal cancer
Background and aim" Inflammatory bowel disease"(IBD) is a chronic, relapsing inflammatory
disease of the intestinal tract that typically begins at a young age and might transit to …
disease of the intestinal tract that typically begins at a young age and might transit to …
Metabolism-associated molecular classification of colorectal cancer
M Zhang, H Wang, R Peng, F Xu, F Wang… - Frontiers in …, 2020 - frontiersin.org
The high heterogeneity of colorectal cancer (CRC) is the main clinical challenge for
individualized therapies. Molecular classification will contribute to drug discovery and …
individualized therapies. Molecular classification will contribute to drug discovery and …
A specific inducible nitric oxide inhibitor, ONO‐1714 attenuates inflammation‐related large bowel carcinogenesis in male ApcMin/+ mice
H Kohno, M Takahashi, Y Yasui… - … journal of cancer, 2007 - Wiley Online Library
It is generally assumed that inflammation influences carcinogenesis. We previously reported
that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the ApcMin/+ …
that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the ApcMin/+ …
Clinically relevant anti-inflammatory agents for chemoprevention of colorectal cancer: new perspectives
Substantial efforts are underway for prevention of early stages or recurrence of colorectal
cancers (CRC) or new polyp formation by chemoprevention strategies. Several …
cancers (CRC) or new polyp formation by chemoprevention strategies. Several …
TLR-4 signalling accelerates colon cancer cell adhesion via NF-κB mediated transcriptional up-regulation of Nox-1
DP O'Leary, L Bhatt, JF Woolley, DR Gough, JH Wang… - 2012 - journals.plos.org
Surgery induced inflammation is a potent promoter of tumour recurrence and metastasis in
colorectal cancer. The recently discovered family of Nox enzymes represent a major source …
colorectal cancer. The recently discovered family of Nox enzymes represent a major source …
[引用][C] PD-236 defining the signaling pathways and functional role for kynurenine metabolites in the normal and neoplastic colon epithelium
S Santhanam, D Alvarado, A Khouri… - Inflammatory Bowel …, 2017 - LWW
[HTML][HTML] ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition
J Yan, W Duan, Q Gao, T Mao, M Wang, J Duan… - Pharmacological …, 2023 - Elsevier
In our previous multicenter study, we delineated the inherent metabolic features of colorectal
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …
cancer (CRC). Therein, we identified a member of the ectonucleotide pyrophosphatase …
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation
Abstract Aldose reductase (AR; EC 1.1. 1.21), an nicotinamide adenine dinucleotide
phosphate-dependent aldo–keto reductase, has been shown to be involved in oxidative …
phosphate-dependent aldo–keto reductase, has been shown to be involved in oxidative …