Substantial efforts are underway for prevention of early stages or recurrence of colorectal
cancers (CRC) or new polyp formation by chemoprevention strategies. Several …

Abstract Aldose reductase (AR; EC 1.1. 1.21), an nicotinamide adenine dinucleotide
phosphate-dependent aldo–keto reductase, has been shown to be involved in oxidative …

Oxidative stress is crucial to the biology of tumors. Oxidative stress' potential predictive
significance in colorectal cancer (CRC) has not been studied; nevertheless here, we …

Background It has been widely accepted that angiogenesis plays fundamental roles in
colorectal cancer development, and therapeutic targeting of this pathway has achieved …

Significance: Reactive oxygen species (ROS) are critical to normal cellular function with
redox homeostasis achieved by balancing ROS production with removal through …

The connection between inflammation and colorectal cancer (CRC) has been well
recognized, and numerous related molecular mechanisms have been uncovered. To gain …

Simple Summary Colon cancer is a major health problem, and its occurrence is rising
particularly among young adults. Preventing this cancer is urgently needed. Earlier studies …

Highlights•Redox-related transcription factor upregulation characterizes inflammation-
related cancer.•NADPH oxidase-dependent ROS are associated with inflammation and …

Orientin, a C-glycosyl dietary flavone profusely found in rooibos tea and passion fruit have
gained much attention owing to their multiple pharmacological potentials. The present study …

The discovery of bioactive compounds from natural sources entails an extremely lengthy
process due to the timescale and complexity of traditional methodologies. In our study, we …