The epithelial–mesenchymal transition (EMT), one of the main mechanisms underlying
development of cancer metastasis, induces stem-like properties in epithelial cells. Bmi1 is a …

Breast cancer is the leading cause of cancer-related deaths in the United States. The
majority of deaths (90%) in breast cancer patients is caused by invasion and metastasis–two …

Abstract TRAF-binding domain (Trabid), one of deubiquitination enzymes, was recently
reported to activate Wnt/β-catenin signaling pathway. However, the role of Trabid in tumors …

The epithelial-mesenchymal transition (EMT) converts epithelial tumor cells into invasive
and metastatic cancer cells, leading to mortality in cancer patients. Although TWIST is a …

TWIST, a helix-loop-helix transcription factor, is highly expressed in many types of human
cancer. We have previously found that TWIST confers prostate cancer cells with an …

A mutation within one allele of the p53 tumor suppressor gene can inactivate the remaining
wild-type allele in a dominant-negative manner and in some cases can exert an additional …

Type II endometrial carcinoma is an aggressive subtype of endometrial cancer (EC).
TWIST1, a helix‐loop‐helix transcription regulator, is known to induce epithelial …

The mechanisms controlling tumour-induced angiogenesis are presently not clear. In
principle, angiogenesis can be achieved through the activation of endothelial cells in …

Background Twist1 is known to be involved in epithelial–mesenchymal transition (EMT) and
tumor progression. However, its specific role is different depending on the type of cancer …

SET8 is implicated in transcriptional regulation, heterochromatin formation, genomic
stability, cell‐cycle progression, and development. As such, it is predicted that SET8 might …