Hepatocyte viability and adenosine triphosphate content decrease linearly over time during conventional cold storage of rat liver grafts

TA Berendsen, ML Izamis, H Xu, Q Liu, M Hertl… - Transplantation …, 2011 - Elsevier
Introduction The gold standard in organ preservation is static cold storage (SCS) using
University of Wisconsin solution (UW). Although it is well-known that there is a finite limit to …

[HTML][HTML] Liver transplantation after ex vivo normothermic machine preservation: a phase 1 (first-in-man) clinical trial

R Ravikumar, W Jassem, H Mergental, N Heaton… - American Journal of …, 2016 - Elsevier
The number of donor organs suitable for liver transplantation is restricted by cold
preservation and ischemia–reperfusion injury. We present the first patients transplanted …

[HTML][HTML] The Role of Normothermic Machine Perfusion in Extended Criteria Donor Grafts: A New Direction in Liver Graft Assessment and Preservation

D Malkawi, K Savsani, A Alfonso, SD Lee, N James… - Livers, 2023 - mdpi.com
Despite improvements in short-term and long-term outcomes of liver transplant patients, the
discrepancy between the number of available livers and transplant candidates continues to …

Normothermic machine perfusion of donor livers for transplantation in the United States: a randomized controlled trial

WC Chapman, AS Barbas, AM D'Alessandro… - Annals of …, 2023 - journals.lww.com
Objective: To compare conventional low-temperature storage of transplant donor livers
[static cold storage (SCS)] with storage of the organs at physiological body temperature …

Organ preservation

HU Spiegel, D Palmes - Transplantation surgery, 2001 - Springer
The emergence of organ transplantation as an accepted therapeutic procedure is primarily
due to the refinement of surgical techniques and the development of immunosuppressive …

New preservation solutions for use in liver transplantation

DC Mulligan, KS Reddy, AA Moss Jr - Current opinion in organ …, 2004 - journals.lww.com
New preservation solutions for use in liver transplantation : Current Opinion in Organ
Transplantation New preservation solutions for use in liver transplantation : Current Opinion in …

[HTML][HTML] Machine perfusion: cold versus warm, versus neither. update on clinical trials

E Bonaccorsi-Riani, IMA Brüggenwirth… - Seminars in liver …, 2020 - thieme-connect.com
Machine perfusion (MP) preservation is potentially one of the most significant improvements
in the field of liver transplantation in the last 20 years, and it has been considered a …

Preservation methods for kidney and liver

CY Lee, MJ Mangino - Organogenesis, 2009 - Taylor & Francis
With the successful testing of the immunosuppressive effects of cyclosporine in transplant
patients in 1978, the field of organ transplants began an exponential growth. With that, the …

[PDF][PDF] Normothermic machine perfusion in liver transplantation: feasibility and promise of avoiding recooling before engrafting

F di Francesco, D Pagano, G Martucci… - Liver …, 2019 - Wiley Online Library
It is well known that the ischemia and the reperfusion processes are distinct
nonimmunological events that negatively impact graft outcome and induce delayed graft …

Transplantation of a human liver following 3 days of ex situ normothermic preservation

PA Clavien, P Dutkowski, M Mueller… - Nature …, 2022 - nature.com
Current organ preservation methods provide a narrow window (usually< 12 hours) to
assess, transport and implant donor grafts for human transplantation. Here we report the …