In vitro and in vivo evaluation of actively targetable nanoparticles for paclitaxel delivery

Z Xu, W Gu, J Huang, H Sui, Z Zhou, Y Yang… - International journal of …, 2005 - Elsevier
The aim of the present work was to assess the merits of an actively targetable nanoparticles
(ATN), PEG-coated biodegradable polycyanoacrylate nanoparticles (PEG-nanoparticles) …

Development, characterization and biological in vitro assays of paclitaxel-loaded PCL polymeric nanoparticles

JP Abriata, RC Turatti, MT Luiz, GL Raspantini… - Materials Science and …, 2019 - Elsevier
Adenocarcinoma is the most lethal gynecologic tumor and treatment usually consists in
surgery followed by chemotherapy. However, the chemotherapy benefits are eventually …

Paclitaxel drug delivery systems: Focus on nanocrystals' surface modifications

R Haddad, N Alrabadi, B Altaani, T Li - Polymers, 2022 - mdpi.com
Paclitaxel (PTX) is a chemotherapeutic agent that belongs to the taxane family and which
was approved to treat various kinds of cancers including breast cancer, ovarian cancer …

Nanoparticles of poly(D,L‐lactide)/methoxy poly(ethylene glycol)‐poly(D,L‐lactide) blends for controlled release of paclitaxel

Y Dong, SS Feng - … of Biomedical Materials Research Part A …, 2006 - Wiley Online Library
Paclitaxel is one of the best antineoplastic drugs found in nature in the past decades, which
has excellent therapeutic effects against a wide spectrum of cancers. Because of its high …

Targeted delivery of paclitaxel using folate-decorated poly (lactide)–vitamin E TPGS nanoparticles

J Pan, SS Feng - Biomaterials, 2008 - Elsevier
We synthesized nanoparticles (NPs) of the blend of two-component copolymers for targeted
chemotherapy with paclitaxel used as model drug. One component is poly (lactide)–d-α …

Formulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery

Y Wang, X Li, L Wang, Y Xu, X Cheng… - International journal of …, 2011 - Taylor & Francis
Paclitaxel is a diterpenoid isolated from Taxus brevifolia. It is effective for various cancers,
especially ovarian and breast cancer. Due to its aqueous insolubility, it is administered …

A novel nanoparticle formulation for sustained paclitaxel delivery

WJ Trickler, AA Nagvekar, AK Dash - Aaps Pharmscitech, 2008 - Springer
Purpose To develop a novel nanoparticle drug delivery system consisting of chitosan and
glyceryl monooleate (GMO) for the delivery of a wide variety of therapeutics including …

Discriminated effects of thiolated chitosan-coated pMMA paclitaxel-loaded nanoparticles on different normal and cancer cell lines

SP Akhlaghi, S Saremi, SN Ostad, R Dinarvand… - … , Biology and Medicine, 2010 - Elsevier
The aim of the present work was to prepare and characterize poly (methyl methacrylate)
nanoparticles coated by chitosan–glutathione conjugate so as to encapsulate insoluble …

[HTML][HTML] Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability

MM Badran, AH Alomrani, GI Harisa, AE Ashour… - Biomedicine & …, 2018 - Elsevier
In the present study, docetaxel (DTX)-loaded poly (lactic-co-glycolic acid)(PLGA) and
polycaprolactone (PCL) nanoparticles were successfully prepared and coated with chitosan …

Nanoscale drug delivery systems for cancer therapy using paclitaxel—A review of challenges and latest progressions

G Mustafa, D Hassan, G Ruiz-Pulido… - Journal of Drug Delivery …, 2023 - Elsevier
Paclitaxel (PTX) is an effective anticancer chemical with a broad spectrum that was primarily
obtained from a curative shrub, specifically the bark of Taxus brevifolia tree. It belongs to a …