PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy

Y Yoshizawa, Y Kono, K Ogawara, T Kimura… - International journal of …, 2011 - Elsevier
To find out potent paclitaxel (PTX) formulations for cancer chemotherapy, we formulated PTX
in O/W emulsion and liposome selected as candidates of nanocarriers for PTX. Surface …

Biodegradable polymeric nanoparticles as the delivery carrier for drug

K Zhao, D Li, C Shi, X Ma, G Rong, H Kang… - Current Drug …, 2016 - ingentaconnect.com
Background: Drug research and development has entered into the new epoch of innovation
formulation, and the drug delivery system has been in the forefront of pharmaceutical …

Preferential tumor accumulation and desirable interstitial penetration of poly (lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and …

G Wang, Y Chen, P Wang, Y Wang, H Hong, Y Li… - Acta biomaterialia, 2016 - Elsevier
Despite advances in polymeric nanoparticles (NPs) as effective delivery systems for
anticancer drugs, rapid clearance from blood and poor penetration capacity in …

In-vivo efficacy of novel paclitaxel nanoparticles in paclitaxel-resistant human colorectal tumors

JM Koziara, TR Whisman, MT Tseng… - Journal of controlled …, 2006 - Elsevier
Colloidal carriers have been shown to improve tumor therapy by increased drug delivery
into tumor sites resulting directly from the enhanced permeability and retention effect (EPR) …

PLA/PLGA nanoparticles for sustained release of docetaxel

T Musumeci, CA Ventura, I Giannone, B Ruozi… - International journal of …, 2006 - Elsevier
This study investigates the potentiality of nanosphere colloidal suspensions as sustained
release systems for intravenous administration of docetaxel (DTX). Nanospheres were …

Controlled preparation and antitumor efficacy of vitamin E TPGS-functionalized PLGA nanoparticles for delivery of paclitaxel

G Wang, B Yu, Y Wu, B Huang, Y Yuan… - International journal of …, 2013 - Elsevier
Vitamin E TPGS-functionalized polymeric nanoparticles have been developed as a
promising drug delivery platform in recent years. Obtaining reproducible monodisperse …

Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization

X Dong, CA Mattingly, M Tseng, M Cho… - European journal of …, 2009 - Elsevier
The objective of these studies was to develop Cremophor-free lipid-based paclitaxel (PX)
nanoparticle formulations prepared from warm microemulsion precursors. To identify and …

Novel docetaxel-loaded nanoparticles based on PCL-Tween 80 copolymer for cancer treatment

Y Ma, Y Zheng, X Zeng, L Jiang, H Chen… - International journal …, 2011 - Taylor & Francis
Background The formulation of docetaxel available for clinical use (Taxotere®) contains a
high concentration of polysorbate 80 (Tween 80). After incorporation of Tween 80 into poly …

Poly (lactide)–vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel

SS Feng, L Mei, P Anitha, CW Gan, W Zhou - Biomaterials, 2009 - Elsevier
Four systems of nanoparticles of biodegradable polymers were developed in this research
for oral delivery of anticancer drugs with Docetaxel used as a model drug, which include the …

Poly (ethylene oxide)-modified poly (β-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery

A Potineni, DM Lynn, R Langer, MM Amiji - Journal of Controlled Release, 2003 - Elsevier
The main objective of this study was to develop and characterize a pH-sensitive
biodegradable polymeric nanoparticulate system for tumor-selective paclitaxel delivery. A …