Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …

The design and syntheses of monofunctionalized enterobactin (Ent, l-and d-isomers)
scaffolds where one catecholate moiety of enterobactin houses an alkene, aldehyde, or …

Bacterial iron uptake machinery can be hijacked for the targeted delivery of antibiotics into
pathogens by attaching antibiotics to siderophores, iron chelators that are employed by …

The design, synthesis, and characterization of enterobactin–antibiotic conjugates, hereafter
Ent-Amp/Amx, where the β-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are …

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores
are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is …

The global crisis of untreatable microbial infections necessitates the design of new
antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire …

Many bacteria, including numerous human pathogens, synthesize small molecules known
as siderophores to scavenge iron. Enterobactin, a siderophore produced by enteric bacteria …

Bacteria often produce siderophores to facilitate iron uptake. One of the most studied
siderophores is enterobactin, the macrolactone trimer of 2, 3-dihydroxybenzoyl-l-serine …

Conspectus This Account describes fundamental chemistry that promoted the discovery of
new antibiotics. Specifically, the NH acidity of simple hydroxamic acid derivatives facilitated …

The success of precision medicine coupled with the disappointing impact of broad-spectrum
antibiotic use on microbiome stability and bacterial resistance, has triggered a shift in …