Esterase-catalyzed siderophore hydrolysis activates an enterobactin–ciprofloxacin conjugate and confers targeted antibacterial activity
W Neumann, M Sassone-Corsi… - Journal of the …, 2018 - ACS Publications
Enteric Gram-negative bacteria, including Escherichia coli, biosynthesize and deploy the
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …
triscatecholate siderophore enterobactin (Ent) in the vertebrate host to acquire iron, an …
Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds …
T Zheng, JL Bullock, EM Nolan - Journal of the American …, 2012 - ACS Publications
The design and syntheses of monofunctionalized enterobactin (Ent, l-and d-isomers)
scaffolds where one catecholate moiety of enterobactin houses an alkene, aldehyde, or …
scaffolds where one catecholate moiety of enterobactin houses an alkene, aldehyde, or …
Evaluation of a reducible disulfide linker for siderophore-mediated delivery of antibiotics
W Neumann, EM Nolan - JBIC Journal of Biological Inorganic Chemistry, 2018 - Springer
Bacterial iron uptake machinery can be hijacked for the targeted delivery of antibiotics into
pathogens by attaching antibiotics to siderophores, iron chelators that are employed by …
pathogens by attaching antibiotics to siderophores, iron chelators that are employed by …
Enterobactin-Mediated Delivery of β-Lactam Antibiotics Enhances Antibacterial Activity against Pathogenic Escherichia coli
T Zheng, EM Nolan - Journal of the American Chemical Society, 2014 - ACS Publications
The design, synthesis, and characterization of enterobactin–antibiotic conjugates, hereafter
Ent-Amp/Amx, where the β-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are …
Ent-Amp/Amx, where the β-lactam antibiotics ampicillin (Amp) and amoxicillin (Amx) are …
Enterobactin: an archetype for microbial iron transport
KN Raymond, EA Dertz, SS Kim - Proceedings of the …, 2003 - National Acad Sciences
Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores
are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is …
are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is …
Heavy-Metal Trojan Horse: Enterobactin-Directed Delivery of Platinum(IV) Prodrugs to Escherichia coli
C Guo, EM Nolan - Journal of the American Chemical Society, 2022 - ACS Publications
The global crisis of untreatable microbial infections necessitates the design of new
antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire …
antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire …
How pathogenic bacteria evade mammalian sabotage in the battle for iron
Many bacteria, including numerous human pathogens, synthesize small molecules known
as siderophores to scavenge iron. Enterobactin, a siderophore produced by enteric bacteria …
as siderophores to scavenge iron. Enterobactin, a siderophore produced by enteric bacteria …
Biosynthetic considerations of triscatechol siderophores framed on serine and threonine macrolactone scaffolds
Bacteria often produce siderophores to facilitate iron uptake. One of the most studied
siderophores is enterobactin, the macrolactone trimer of 2, 3-dihydroxybenzoyl-l-serine …
siderophores is enterobactin, the macrolactone trimer of 2, 3-dihydroxybenzoyl-l-serine …
Design and syntheses of new antibiotics inspired by nature's quest for iron in an oxidative climate
Conspectus This Account describes fundamental chemistry that promoted the discovery of
new antibiotics. Specifically, the NH acidity of simple hydroxamic acid derivatives facilitated …
new antibiotics. Specifically, the NH acidity of simple hydroxamic acid derivatives facilitated …
[HTML][HTML] Siderophores: chemical tools for precise antibiotic delivery
D Rodríguez, C González-Bello - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
The success of precision medicine coupled with the disappointing impact of broad-spectrum
antibiotic use on microbiome stability and bacterial resistance, has triggered a shift in …
antibiotic use on microbiome stability and bacterial resistance, has triggered a shift in …