Large-bodied organisms have more cells that can potentially turn cancerous than small-
bodied organisms, imposing an increased risk of developing cancer. This expectation …

A major constraint on the evolution of large body sizes in animals is an increased risk of
developing cancer. There is no correlation, however, between body size and cancer risk …

The risk of developing cancer is correlated with body size and lifespan within species.
Between species, however, there is no correlation between cancer and either body size or …

Importance Evolutionary medicine may provide insights into human physiology and
pathophysiology, including tumor biology. Objective To identify mechanisms for cancer …

Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger,
long-lived organisms owing to their greater number of cell divisions, and thus increased …

Whales have 1000-fold more cells than humans and mice have 1000-fold fewer; however,
cancer risk across species does not increase with the number of somatic cells and the …

Evolving to become bigger and/or longer lived should increase cancer susceptibility, but this
predicted increase is not observed, a contradiction named Peto's paradox. A solution is that …

Comparative oncology is an understudied field of science. We are far from understanding
the key mechanisms behind Peto's paradox, ie understanding how long-lived and large …

Disease susceptibility and resistance are important factors for the conservation of
endangered species, including elephants. We analyzed pathology data from 26 zoos and …

The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-
lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 …