Ultraviolet radiation and melanomagenesis: from mechanism to immunotherapy

X Sun, N Zhang, C Yin, B Zhu, X Li - Frontiers in Oncology, 2020 - frontiersin.org
Melanoma is the deadliest form of skin cancer, and nearly 90% of melanomas are believed
to be caused by ultraviolet radiation (UVR), mainly from sunlight. UVR induces DNA …

Mechanisms and prevention of UV‐induced melanoma

A Sample, YY He - Photodermatology, photoimmunology & …, 2018 - Wiley Online Library
Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

AQ Khan, JB Travers, MG Kemp - Environmental and molecular …, 2018 - Wiley Online Library
The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

[HTML][HTML] Ultraviolet radiation-mediated development of cutaneous melanoma: An update

G Emri, G Paragh, Á Tósaki, E Janka, S Kollár… - … of Photochemistry and …, 2018 - Elsevier
Ultraviolet (UV) light is absorbed by nucleic acids, proteins or other endogenous
chromophores, such as porphyrins, flavins and melanin, triggering biological processes in …

Oxidative stress and genotoxicity in melanoma induction: impact on repair rather than formation of DNA damage?

T Douki - Photochemistry and Photobiology, 2020 - Wiley Online Library
Keratinocytes and melanocytes, two cutaneous cell types located within the epidermis, are
the origin of most skin cancers, namely carcinomas and melanomas. These two types of …

How sunlight causes melanoma

L Garibyan, DE Fisher - Current oncology reports, 2010 - Springer
The incidence of melanoma has continued to rise dramatically over the past few decades,
especially in young females. Due to the deadly nature of this disease, melanoma has …

UVA Radiation, DNA damage, and melanoma

SG Jin, F Padron, GP Pfeifer - ACS omega, 2022 - ACS Publications
Melanoma is a lethal type of skin tumor that has been linked with sunlight exposure chiefly in
fair-skinned human populations. Wavelengths from the sun that can reach the earth's …

Stepping up melanocytes to the challenge of UV exposure

ZA Abdel‐Malek, AL Kadekaro… - Pigment cell & …, 2010 - Wiley Online Library
Exposure to solar ultraviolet radiation (UV) is the main etiological factor for skin cancer,
including melanoma. Cutaneous pigmentation, particularly eumelanin, afforded by …

Ultraviolet radiation and cutaneous malignant melanoma

C Jhappan, FP Noonan, G Merlino - Oncogene, 2003 - nature.com
Recent years have seen a steady rise in the incidence of cutaneous malignant melanoma
worldwide. Although it is now appreciated that the key to understanding the process by …

Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma

A Brozyna, B Zbytek, J Granese… - Expert review of …, 2007 - Taylor & Francis
Melanoma constitutes 4–5% of all skin cancers but it contributes to 71–80% of skin cancer
deaths. UV light affects cell and tissue homeostasis owing to its damaging effects on DNA …