In silico molecular docking and dynamic simulation of anti-cholinesterase compounds from the extract of Catunaregam spinosa for possible treatment of Alzheimer's …

S Thandivel, P Rajan, T Gunasekar, A Arjunan, S Khute… - Heliyon, 2024 - cell.com
Abstract Alzheimer's disease (AD), is characterized by a progressive loss of cognitive
abilities as well as behavioral symptoms including disorientation, trouble solving problems …

Molecular docking and dynamics simulation approach of Camellia sinensis leaf extract derived compounds as potential cholinesterase inhibitors

ME Hosen, MS Rahman, MO Faruqe… - In Silico …, 2023 - Springer
The tea plant (Camellia sinensis) belongs to the family Theaceae and contains many
phytochemicals that are effective against various diseases, including neurodegenerative …

[PDF][PDF] Quantitative analysis and in silico molecular docking screening for acetylcholinesterase inhibitor and ADME prediction of coumarins and carbazole alkaloids …

B Sungthong, K Sithon, P Panyatip, S Tadtong… - Rec Nat Prod, 2022 - acgpubs.org
Coumarins and carbazole alkaloids are natural compounds, often with neurological
properties, especially as acetylcholinesterase inhibitors. In order to screen the candidate …

Assessing the potential of Psidium guajava derived phytoconstituents as anticholinesterase inhibitor to combat Alzheimer's disease: an in-silico and in-vitro …

K Bhattacharya, A Bhattacharjee… - Journal of Biomolecular …, 2024 - Taylor & Francis
Acetylcholinesterase (AChE) inhibitors play a crucial role in the treatment of Alzheimer's
disease. These drugs increase acetylcholine levels by inhibiting the enzyme responsible for …

Identification of the most potent acetylcholinesterase inhibitors from plants for possible treatment of Alzheimer's disease: A computational approach

B Sarkar, S Alam, TK Rajib, SS Islam, Y Araf… - Egyptian Journal of …, 2021 - Springer
Background Being one of the rapidly growing dementia type diseases in the world,
Alzheimer's disease (AD) has gained much attention from researchers in the recent …

In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile

C Remya, KV Dileep, I Tintu, EJ Variyar… - Journal of molecular …, 2013 - Springer
Acetylcholinesterase (AChE) inhibitors are currently in focus for the pharmacotherapy of
Alzheimer's disease (AD). These inhibitors increase the level of acetylcholine in the brain …

In silico and in vitro anti-AChE activity investigations of constituents from Mytragyna speciosa for Alzheimer's disease treatment

W Innok, A Hiranrat, N Chana… - Journal of Computer …, 2021 - Springer
Acetylcholinesterase (AChE), one of the major therapeutic strategies for the treatment of
Alzheimer's disease (AD) is to increase the acetylcholine (ACh) level in the brain by …

[HTML][HTML] In silico molecular docking analysis of potential anti-alzheimer's compounds present in chloroform extract of Carissa carandas leaf using gas chromatography …

SR Kareti, P Subash - Current Therapeutic Research, 2020 - Elsevier
Background: The current treatment of Alzheimer's disease (AD) is far from adequate. AD can
be treated by inhibiting either β-amyloid protein deposition or acetylcholinesterase enzyme …

Ajmalicine and its Analogues against AChE and BuChE for the Management of Alzheimer's Disease: An In-silico study

S Liu, M Dang, Y Lei, SS Ahmad… - Current …, 2020 - ingentaconnect.com
Background: Alzheimer's disease (AD) is the most well-known reason for disability in
persons aged greater than 65 years worldwide. AD influences the part of the brain that …

Computational exploration of phytochemicals as potent inhibitors of acetylcholinesterase enzyme in Alzheimer's disease

B Sarkar, MA Ullah, MNI Prottoy - medRxiv, 2020 - medrxiv.org
Alzheimer's Disease (AD) is the most common type of age related dementia in the world.
Many hypotheses shed light on several reasons that lead to AD development. The …