In type 2 diabetes, pancreatic β-cells cannot secret enough insulin compensate for insulin
resistance, which are often accompanied by abnormality in lipid metabolism such as …

Background: Increased levels of plasma cholesterol are a common feature of patient of type
2 diabetes. However, the links between elevated levels of low-density lipoprotein (LDL) and …

Dysfunction of β-cell is one of major characteristics in the pathogenesis of type 2 diabetes.
The combination of obesity and type 2 diabetes, characterized as 'diabesity', is associated …

Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …

NAD (P) H: quinone oxidoreductase 1 (NQO1) has been known to protect cells against
stressors, including the diabetogenic reagent streptozotocin (STZ). The present study …

It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by
oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study …

Elevated plasma concentration of the pro-atherogenic oxidized low density lipoprotein
cholesterol (LDL) triggers adverse effects in pancreatic beta-cells and is associated with …

In type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and
survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in …

Overproduction of reactive oxygen species (ROS) or exhaustion of antioxidants may cause
oxidative stress which is a major factor of defective insulin secretion and increases …

Several lines of recent evidence provided compelling evidence to suggest increased
generation of reactive oxygen species (ROS) as causal for mitochondrial dysregulation and …