Cardiovascular malformations are the most common type of birth defect and result in
significant mortality worldwide. The etiology for the majority of these anomalies remains …

Background: Many genes have been implicated in the development of congenital heart
disease (CHD). Next-generation sequencing offers opportunities for genetic testing but is …

Congenital heart disease (CHD) is the most common major birth defect, but little is known
about its cause. Both environmental and genetic factors have been implicated. The genetic …

Significant advances in the understanding of the molecular and genetic basis of congenital
heart disease have emerged from gene inactivation studies in mice and from human genetic …

Congenital heart disease (CHD) is the most common type of birth defect. Traditionally, a
polygenic model defined by the interaction of multiple genes and environmental factors was …

Congenital heart disease likely results from a complex mixture of environmental and genetic
factors. Recent work has elucidated rare single gene mutations that cause a variety of …

BACKGROUND: Congenital heart disease (CHD) is the most common type of birth defect.
Despite the many advances in our understanding of cardiac development and many genes …

Although congenital heart disease (CHD) is the most common survivable birth defect, the
etiology of most CHD remains unclear. Several lines of evidence from humans and …

Twenty years ago, chromosomal abnormalities were the only identifiable genetic causes of a
small fraction of congenital heart defects (CHD). Today, a de novo or inherited genetic …

Congenital heart defects (CHDs) affect 1–2% of newborn children and are the leading cause
of death in infants under 1 year of age. CHDs represent the single largest class of birth …