Evidence for the heterotetrameric structure of the adenosine A2A–dopamine D2 receptor complex

V Casadó-Anguera, J Bonaventura… - Biochemical Society …, 2016 - portlandpress.com
Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel
targets for drug development. Accumulating evidence indicates that GPCRs can form …
被引用次数：39 相关文章 所有 4 个版本
[HTML] nih.gov

Allosteric mechanisms within the adenosine A2A–dopamine D2 receptor heterotetramer

S Ferré, J Bonaventura, D Tomasi, G Navarro… - …, 2016 - Elsevier
The structure constituted by a G protein coupled receptor (GPCR) homodimer and a G
protein provides a main functional unit and oligomeric entities can be viewed as multiples of …
被引用次数：110 相关文章 所有 7 个版本
[HTML] frontiersin.org

[HTML][HTML] Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer

DO Borroto-Escuela, D Rodriguez… - Frontiers in …, 2018 - frontiersin.org
The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell
membrane and allosteric interactions across the A2AR–D2R heteromer represent a target …
被引用次数：69 相关文章 所有 9 个版本

Adenosine A2A Receptor-Antagonist/Dopamine D2 Receptor-Agonist Bivalent Ligands as Pharmacological Tools to Detect A2A-D2 Receptor Heteromers

A Soriano, R Ventura, A Molero, R Hoen… - Journal of medicinal …, 2009 - ACS Publications
Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …
被引用次数：179 相关文章 所有 8 个版本
[HTML] nih.gov

Molecular determinants of A2AR–D2R allosterism: role of the intracellular loop 3 of the D2R

V Fernández‐Dueñas, M Gómez‐Soler… - Journal of …, 2012 - Wiley Online Library
In the CNS, an antagonistic interaction has been shown between adenosine A2A and
dopamine D2 receptors (A2 AR s and D2Rs) that may be relevant both in normal and …
被引用次数：76 相关文章 所有 9 个版本

Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives

D Guidolin, M Marcoli, C Tortorella, G Maura… - Progress in Molecular …, 2020 - Elsevier
The discovery of receptor-receptor interactions in the early 1980s, together with a more
accurate focusing of allosteric mechanisms in proteins, expanded the knowledge on the G …
被引用次数：17 相关文章 所有 4 个版本
[DOC] csic.es

Heterobivalent Ligand for the Adenosine A2A–Dopamine D2 Receptor Heteromer

D Pulido, V Casado-Anguera… - Journal of medicinal …, 2022 - ACS Publications
AG protein-coupled receptor heteromer that fulfills the established criteria for its existence in
vivo is the complex between adenosine A2A (A2AR) and dopamine D2 (D2R) receptors …
被引用次数：16 相关文章 所有 5 个版本
[HTML] nih.gov

Dopamine D2 receptor-mediated modulation of adenosine A2A receptor agonist binding within the A2AR/D2R oligomer framework

V Fernández-Dueñas, M Gómez-Soler, X Morató… - Neurochemistry …, 2013 - Elsevier
The molecular interaction between adenosine A2A and dopamine D2 receptors (A2ARs and
D2Rs, respectively) within an oligomeric complex has been postulated to play a pivotal role …
被引用次数：33 相关文章 所有 8 个版本
[PDF] jst.go.jp

Functional expression of single-chain heterodimeric G-protein-coupled receptors for adenosine and dopamine

T Kamiya, O Saitoh, H Nakata - Cell structure and function, 2005 - jstage.jst.go.jp
The direct homo-and heteromeric association between G-protein-coupled receptors
(GPCRs), adenosine A2A receptor (A2AR) and dopamine D2 receptor (D2R), occurs …
被引用次数：9 相关文章 所有 9 个版本
[PDF] academia.edu

A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R

DO Borroto-Escuela, D Marcellino, M Narvaez… - Biochemical and …, 2010 - Elsevier
Evidence exists that the adenosine receptor A2AR and the dopamine receptor D2R form
constitutive heteromers in living cells. Mass spectrometry and pull-down data showed that …
被引用次数：96 相关文章 所有 7 个版本