Transforming growth factor-β (TGF-β) strongly promotes renal tubulointerstitial fibrosis, but
the cellular target that mediates its profibrotic actions has not been clearly identified. While in …

TGF-β plays a key role in upregulating matrix production in injury-induced renal fibrosis, but
how TGF-β signaling in distinct compartments of the kidney, such as specific segments of the …

Transforming growth factor β1 (TGF-β1) contributes to the accumulation of extracellular
matrix (ECM) in the tubulointerstitial space in chronic renal diseases. Identification of target …

Tubulointerstitial fibrosis mediates the development of end-stage renal disease from renal
injuries of all etiologies and is considered an important predictor of renal survival …

Tubulointerstitial fibrosis is the final common result of a variety of progressive injuries
leading to chronic renal failure. Transforming growth factor-β (TGF-β) is reportedly …

Macrophage infiltration is a prominent feature of the innate immune response to kidney
injury. The persistence of macrophages is associated with tubulointerstitial fibrosis and …

Kidney fibrosis is characterized by the development of myofibroblasts originating from
resident kidney and immigrating cells. Myofibroblast formation and extracellular matrix …

Mechanisms do, however, exist within the tubulointerstium that promote tubulointerstitial
injury [5–9], a view strengthened by Johnson et al [4]. Interstitial fibrosis independently …

Renal tubulointerstitial fibrosis is the common final pathway leading to end-stage renal
failure. Tubulointerstitial fibrosis is characterized by fibroblast proliferation and excessive …

Renal fibrosis is the inevitable consequence of an excessive accumulation of extracellular
matrix that occurs in virtually every type of chronic kidney disease. The pathogenesis of …