Cell migration is a physical process central to life. Among others, it regulates
embryogenesis, tissue regeneration, and tumor growth. Therefore, understanding and …

How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis–traditionally defined as cell migration …

Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal
dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to …

Directed cell migration is essential for cells to efficiently migrate in physiological and
pathological processes. While migrating in their native environment, cells interact with …

Increasing experimental evidence validates that both the elastic stiffness and viscosity of the
extracellular matrix regulate mesenchymal cell behavior, such as the rational switch …

Living cells display various directed motility in response to rigidity gradients of extracellular
matrix. Some cells move preferentially toward stiff matrix (durotaxis), while some cells move …

Collective cell migration is regulated by a complex set of mechanical interactions and
cellular mechanisms. Collective migration emerges from mechanisms occurring at single …

Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness,
has been proposed as a mechanism driving directed migration. Despite the lack of evidence …

Cells exhibit qualitatively different behaviors on substrates with different rigidities. The fact
that cells are more polarized on the stiffer substrate motivates us to construct a two …

How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …