Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels

MR Arkenberg, HD Nguyen, CC Lin - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
In recent years, dynamic,'click'hydrogels have been applied in numerous biomedical
applications. Owing to the mild, cytocompatible, and highly specific reaction kinetics, a …

Bioorthogonal strategies for engineering extracellular matrices

CM Madl, SC Heilshorn - Advanced Functional Materials, 2018 - Wiley Online Library
Hydrogels are commonly used as engineered extracellular matrix (ECM) mimics in
applications ranging from tissue engineering to in vitro disease models. Ideal mechanisms …

Covalently Crosslinked hydrogels via step‐growth reactions: crosslinking chemistries, polymers, and clinical impact

Y Gao, K Peng, S Mitragotri - Advanced Materials, 2021 - Wiley Online Library
Hydrogels are an important class of biomaterials with the unique property of high‐water
content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels …

Supramolecular and dynamic covalent hydrogel scaffolds: from gelation chemistry to enhanced cell retention and cartilage regeneration

L Teng, Y Chen, YG Jia, L Ren - Journal of Materials Chemistry B, 2019 - pubs.rsc.org
Supramolecular and dynamic covalent crosslinking (DCC) hydrogels not only display
unique physicochemical properties that can mimic the dynamic extracellular matrix (ECM) …

Bioorthogonal click chemistry: an indispensable tool to create multifaceted cell culture scaffolds

MA Azagarsamy, KS Anseth - 2013 - ACS Publications
Over the past decade, bioorthogonal click chemistry has led the field of biomaterial science
into a new era of diversity and complexity by its extremely selective, versatile, and …

Designing hydrogels for 3D cell culture using dynamic covalent crosslinking

M Rizwan, AEG Baker… - Advanced Healthcare …, 2021 - Wiley Online Library
Designing simple biomaterials to replicate the biochemical and mechanical properties of
tissues is an ongoing challenge in tissue engineering. For several decades, new …

Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications

B Yin, M Gosecka, M Bodaghi, D Crespy… - Chemical Engineering …, 2024 - Elsevier
Hydrogels have emerged in various biomedical applications, including tissue engineering
and medical devices, due to their ability to imitate the natural extracellular matrix (ECM) of …

Tunable cross-linking and adhesion of gelatin hydrogels via bioorthogonal click chemistry

N Contessi Negrini, A Angelova Volponi… - ACS Biomaterials …, 2021 - ACS Publications
Engineering cytocompatible hydrogels with tunable physico-mechanical properties as a
biomimetic three-dimensional extracellular matrix (ECM) is fundamental to guide cell …

Tuning hydrogels by mixing dynamic cross‐linkers: enabling cell‐instructive hydrogels and advanced bioinks

FLC Morgan, J Fernández‐Pérez… - Advanced …, 2022 - Wiley Online Library
Rational design of hydrogels that balance processability and extracellular matrix (ECM)
biomimicry remains a challenge for tissue engineering and biofabrication. Hydrogels …

Design strategies of stimuli-responsive supramolecular hydrogels relying on structural analyses and cell-mimicking approaches

H Shigemitsu, I Hamachi - Accounts of Chemical Research, 2017 - ACS Publications
Conspectus Stimuli-responsive hydrogels are intriguing biomaterials useful for
spatiotemporal controlled release of drugs, cells, and biological cues, cell engineering for …