Spontaneous autoimmune diabetes development in NOD mice requires both CD8+ and
CD4+ T cells. Three pathogenic CD8+ T cell populations (represented by the G9C8, 8.3, and …

Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a
consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies …

The end-stage immunopathology of type 1 diabetes resulting in β-cell destruction appears to
be strongly dominated by cytotoxic CD8 T lymphocytes (CD8 T cells). However, the …

Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA)
genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly …

Insulin-dependent diabetes mellitus (IDDM) results from the selective destruction of
pancreatic β cells by a T cell-mediated autoimmune process. Insulin and proinsulin are the …

OBJECTIVE To define cellular mechanisms by which B cells promote type 1 diabetes.
RESEARCH DESIGN AND METHODS The study measured islet-specific CD4 T cell …

OBJECTIVE Regulatory T-cells (Tregs) recognizing islet autoantigens are proposed as a key
mechanism in the maintenance of self-tolerance and protection from type 1 diabetes. To …

Type 1 diabetes (T1D) is an autoimmune disease driven by the activation of lymphocytes
against pancreatic β‐cells. Among β‐cell autoantigens, preproinsulin has been ascribed a …

There is an urgent and unmet need for humanized in vivo models of type 1 diabetes to study
immunopathogenesis and immunotherapy, and in particular antigen-specific therapy …

Type 1 diabetes mellitus is a T-cell mediated autoimmune disease in which the insulin-
producing pancreatic beta cells are selectively destroyed. Molecular mimicry and T-cell …