Type 1 diabetes (T1D) is an autoimmune disease driven by the activation of lymphocytes
against pancreatic β‐cells. Among β‐cell autoantigens, preproinsulin has been ascribed a …

Abstract Purpose of Review The genetic susceptibility and dominant protection for type 1
diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with …

Type I (insulin-dependent) diabetes mellitus (IDDM) is an autoimmune disease that results
from the destruction of insulin-secreting pancreatic islet β-cells by autoreactive cells and …

Type 1 diabetes (T1D) is caused by the destruction of insulin-producing islet β cells. CD8 T
cells are prevalent in the islets of T1D patients and are the major effectors of β cell …

Pathogenesis of type 1 diabetes (T1D) is mediated by effector T cells and CD4 Th1 and
Th17T cells have important roles in this process. While effector function of Th1 cells is well …

Type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice is a T‐cell‐
mediated autoimmune disease in which the insulin‐producing pancreatic islet β‐cells are …

Recent studies suggest that insulin is a primary autoantigen for type 1 diabetes. Several
studies have identified preproinsulin (PPI) 76–90 as an immunodominant CD4+ T cell …

Because of anatomical limitations, molecular characterization of islet-inflammatory T-cells in
human insulin-dependent diabetes mellitus (IDDM) has remained elusive. We have isolated …

The 65KD isoform of GAD is considered to be a major target autoantigen in many humans
with autoimmune prediabetes or diabetes. The major histocompatibility complex class II …

Type 1 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading
to insulin deficiency. Although infiltrating immune cells are traditionally considered to …