The cell-cycle inhibitor flavopiridol has been shown to improve recovery from spinal cord
injury in animal models. However, the systemic dose of flavopiridol has side-effects and the …

Spinal cord injury (SCI) is a devastating clinical problem that can lead to permanent motor
dysfunction. Fingolimod (FTY720) is a sphingosine structural analogue, and recently, its …

Abstract Spinal Cord Injury (SCI) is one of the leading causes of physical disability. In this
study, spherical PLGA nanoparticles (NPs) containing ChABC enzyme were manufactured …

During cerebral ischemia‐reperfusion (I‐R) injury, the infiltration of monocyte/macrophages
(Mo/Mφ) into the ischemic penumbra causes inflammatory damage but also regulates tissue …

Objectives: Biomaterials are used to aid in the regeneration of damaged tissue and in
promotion of axonal guidance following spinal cord injury (SCI). In the present study …

Neural stem cells (NSCs) are considered to be prospective replacements for neuronal cell
loss as a result of spinal cord injury (SCI). However, the survival and neuronal differentiation …

Spinal cord injury (SCI) causes delayed secondary biochemical alterations that lead to
tissue loss and associated neurological dysfunction. Up-regulation of cell cycle proteins …

Spinal cord injury (SCI) is an extremely destructive central nervous system lesion. Studies
have shown that NGF can promote nerve regeneration after SCI. However, it cannot produce …

Glial cell line derived neurotrophic factor (GDNF) induces neuronal survival and tissue
repair after spinal cord injury (SCI). A continuous GDNF supply is believed to gain greater …

Spinal cord injury (SCI) is a serious refractory disease of the central nervous system (CNS),
which mostly caused by high-energy trauma. Existing interventions such as hormone shock …