Epigenetic mechanisms have been hypothesized to play a role in the etiology of major
depressive disorder (MDD). In this study, we performed a meta-analysis between two case …

Objective Epigenetic mechanisms have been implicated in the pathogenesis of psychiatric
disorders. The serotonin transporter gene (SLC6A4) is a key candidate gene for depression …

Aberrant DNA methylation in the blood of patients with major depressive disorder (MDD) has
been reported in several previous studies. However, no comprehensive studies using …

BACKGROUND: Epigenetic changes may play a role in the etiology of psychotic diseases. It
has been demonstrated that the serotonin receptor, 5HTR1A, is implicated in schizophrenia …

Electroconvulsive therapy (ECT) is a quick-acting and powerful antidepressant treatment
considered to be effective in treating severe and pharmacotherapy-resistant forms of …

We examined the utility of DNA methylation profiles at the CpG island of SLC6A4 (DMS) as a
diagnostic biomarker for major depression (MD). In addition, the relationship between DMS …

Major depression, because of its recurring and life-threatening nature, is one of the top 10
diseases for global disease burden. Major depression is still diagnosed on the basis of …

Background Depression is a disabling and highly prevalent condition where genetic and
epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA …

Monozygotic (MZ) twin studies constitute a key resource for the dissection of environmental
and biological risk factors for human complex disorders. Given that epigenetic differences …

Background Antidepressant treatment is associated with a high rate of poor response, and
thus, biomarker development is warranted. Methods We aimed to synthesize studies …