Different neurodegenerative disorders often show similar lesions, such as the presence of
amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited …

The pharmacoepigenetics of antipsychotic treatment in severe mental illness is a growing
area of research that aims to understand the interface between antipsychotic treatment and …

Epigenetic modifications in response to traumatic experience and stress are emerging as
important factors in the long-term biological trajectories leading to stress-related psychiatric …

Background Disrupted serotonergic signaling is often a feature of depression and the role of
the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received …

Recent studies imply that there is a tight association between epigenetics and a molecular
mechanism of major depressive disorder (MDD). Epigenetic modifications, ie, DNA …

While genome-wide association studies are ongoing to identify sequence variation
influencing susceptibility to major depressive disorder (MDD), epigenetic marks, such as …

Background Suicidal behavior is a multifactorial, polygenic state that affects millions
worldwide. It is a result of interplay between hereditary and environmental factors, tied …

Covalent modifications of nucleotides, such as methylation or hydroxymethylation of
cytosine, regulate gene expression. Early environmental risk factors play a role in mental …

There is an increasing body of knowledge on the influence of differential DNA methylation of
specific genomic regions in psychiatric disorders. However, fewer studies have addressed …

BackgroundRecent work suggests that epigenetic differences may be associated with
psychiatric disorders. Here we investigate, in a community-based sample, whether …