Hypercholesterolemia is a major risk factor for atherosclerosis. Dysregulation of adipokines
contribute to atherosclerotic diseases. Apelin has recently been shown to be secreted by the …

Apelin, an endogenous ligand for the G protein–coupled receptor (APJ), is widely distributed
within the central nervous system and diverse organs in human and animals. Recent studies …

Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor,
APJ. This novel peptidic signalling pathway is widely represented in the heart and …

Background Apelin, the endogenous ligand for the G protein-coupled apelin receptor, is an
important regulator of the cardiovascular homoeostasis. We previously demonstrated that …

Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a
potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …

A gene encoding a novel class a G-protein-coupled receptor was discovered in 1993 by
homology cloning and was called APJ. It was designated an “orphan” receptor until 1998 …

Because apelin may play an important regulatory role in human cardiac dysfunction, we
investigated alterations in cardiovascular content of apelin and its receptor, APJ, during …

Apelin is the endogenous ligand of the G protein-coupled receptor APJ. Both Apelin and
APJ receptor are widely distributed in various tissues such as heart, brain, limbs, retina and …

Cardiac apelin has recently been suggested to contribute to the pathophysiology of heart
failure (HF) in humans. In animal experiments, its infusion acutely improved systolic as well …

The Apelin/APJ system is involved in a wide range of biological functions. For a long time,
Apelin was thought to be the only ligand for APJ. Recently, a new peptide that acts via APJ …