Background The IMPACT study demonstrated the benefit of interferon beta-1a (IFNβ-1a,
Avonex®) two-year change in disability measured by the Multiple Sclerosis Functional …

Background: Much research has gone into the assessment of function and health-related
quality of life (HRQOL) in those with multiple sclerosis (MS). The Medical Outcomes Study …

Common disability scales in multiple sclerosis (MS) are often weighted towards physical
disability. Non-motor symptoms such as depression, fatigue and pain substantially influence …

Background: Cross-sectional research has demonstrated poorer function and health-related
quality of life (HRQOL) in those with multiple sclerosis (MS) but less is known about change …

Purpose There is substantial interest in testing interventions for improving quality of life
(QOL) and health-related quality of life (HRQOL) in people with multiple sclerosis (MS). Yet …

Objective. To compare patterns of associations of changes in mental and physical health
dimensions of health‐related quality of life (HRQoL) over time with relapse occurrence and …

Purpose The aim of this study was to determine the changes in the health-related quality of
life (HRQoL) and predictors of change among patients with multiple sclerosis (MS) at 3 and …

Background Responsiveness, defined as the ability to detect a meaningful change, is a core
psychometric property of an instrument measuring quality of life (QoL) rarely reported in …

Background: A randomized, placebo-controlled, multicenter study of weekly intramuscular
injections of interferon beta-1a (IFNβ-1a) in relapsing–remitting multiple sclerosis included …

This study examined whether multiple sclerosis (MS) patients (N= 3779) experience change
in their perceived health-related quality of life (HRQOL) over a 5-year period, and …