Nuclear pore interactions with the genome
V Sood, JH Brickner - Current opinion in genetics & development, 2014 - Elsevier
Within the nucleus, chromatin is functionally organized into distinct nuclear compartments.
The nuclear periphery, containing Nuclear Pore Complexes (NPCs), plays an important role …
The nuclear periphery, containing Nuclear Pore Complexes (NPCs), plays an important role …
The nuclear pore complex as a transcription regulator
MC Sumner, J Brickner - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that
mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal …
mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal …
You are who your friends are—nuclear pore proteins as components of chromatin‐binding complexes
M Capelson - FEBS letters, 2023 - Wiley Online Library
Nuclear pore complexes are large multicomponent protein complexes that are embedded in
the nuclear envelope, where they mediate nucleocytoplasmic transport. In addition to …
the nuclear envelope, where they mediate nucleocytoplasmic transport. In addition to …
Nuclear pore proteins and the control of genome functions
A Ibarra, MW Hetzer - Genes & development, 2015 - genesdev.cshlp.org
Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …
Nuclear pore complexes as hubs for gene regulation
MA D'Angelo - Nucleus, 2018 - Taylor & Francis
Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm,
are the largest protein structures of the nuclear envelope. In addition to their role in …
are the largest protein structures of the nuclear envelope. In addition to their role in …
From hypothesis to mechanism: uncovering nuclear pore complex links to gene expression
LT Burns, SR Wente - Molecular and cellular biology, 2014 - Taylor & Francis
The gene gating hypothesis put forth by Blobel in 1985 was an alluring proposal outlining
functions for the nuclear pore complex (NPC) in transcription and nuclear architecture. Over …
functions for the nuclear pore complex (NPC) in transcription and nuclear architecture. Over …
The multifunctional nuclear pore complex: a platform for controlling gene expression
C Ptak, JD Aitchison, RW Wozniak - Current opinion in cell biology, 2014 - Elsevier
In addition to their established roles in nucleocytoplasmic transport, the intimate association
of nuclear pore complexes (NPCs) with chromatin has long led to speculation that these …
of nuclear pore complexes (NPCs) with chromatin has long led to speculation that these …
The nuclear pore complex and the genome: organizing and regulatory principles
P Pascual-Garcia, M Capelson - Current opinion in genetics & …, 2021 - Elsevier
The nuclear pore complex (NPC) is a massive nuclear envelope-embedded protein
complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …
complex, the canonical function of which is to mediate selective nucleocytoplasmic transport …
The nuclear pore complex in cell type-specific chromatin structure and gene regulation
J Sun, Y Shi, E Yildirim - Trends in genetics, 2019 - cell.com
Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key
cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC …
cellular processes, such as cell growth, cell differentiation, and gene regulation. The NPC …
Nuclear pore complexes guardians of the nuclear genome
M Capelson, C Doucet… - Cold Spring Harbor …, 2010 - symposium.cshlp.org
Eukaryotic cell function depends on the physical separation of nucleoplasmic and
cytoplasmic components by the nuclear envelope (NE). Molecular communication between …
cytoplasmic components by the nuclear envelope (NE). Molecular communication between …