Regulation of CD8 T cell expansion and contraction is essential for successful immune
defense against intracellular pathogens. IL-10 is a regulatory cytokine that can restrict T cell …

Various signals during infection influence CD8 T cell memory generation, but these factors
have yet to be fully defined. IL-12 is a proinflammatory cytokine that has been shown to …

IL-10 is an important immunoregulatory cytokine that plays a central role in maintaining a
balance between protective immunity against infection and limiting proinflammatory …

CD8+ T cells are central to the eradication of intracellular pathogens, but they can also act to
limit inflammation and immunopathology. During primary respiratory viral infection CD8+ …

Pathogens use numerous methods to subvert host immune responses, including the
modulation of host IL-10 production by diverse cell types. However, the B cell sources of IL …

Abstract Background Interleukin (IL)-7 promotes the generation, expansion, and survival of
memory T cells. Previous mouse and human studies showed that IL-7 can support immune …

Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral
infection and vaccination. A multitude of inhibitory and stimulatory factors are induced …

Production of IFN-γ by CD4 T cells is generally thought to be mediated by TCR triggering,
however, Ag-nonspecific activation of effector CD8 T cells has been reported in infection …

During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they
lose their ability to respond to antigenic activation. Combinations of IL-12, IL-18, and IL-21 …

Proinflammatory cytokines, such as gamma interferon (IFN-γ), impact aspects of T-cell
responses after infection, including expansion, contraction, and memory formation …