Test-retest reliability and stability of the nicotine metabolite ratio among treatment-seeking smokers
DA Hamilton, MC Mahoney, M Novalen… - Nicotine & Tobacco …, 2015 - academic.oup.com
Introduction: The nicotine metabolite ratio (NMR), the ratio of 3-hydroxycotinine to cotinine, is
a biomarker used in smoking cessation research, with several retrospective studies …
a biomarker used in smoking cessation research, with several retrospective studies …
The nicotine metabolite ratio is associated with early smoking abstinence even after controlling for factors that influence the nicotine metabolite ratio
MJ Chenoweth, RA Schnoll, M Novalen… - Nicotine & Tobacco …, 2016 - academic.oup.com
Introduction: The decrease in smoking rates in North America has plateaued, underscoring
the need for new approaches to treat nicotine dependence. Inter-individual differences in …
the need for new approaches to treat nicotine dependence. Inter-individual differences in …
Nicotine metabolite ratio (NMR) prospectively predicts smoking relapse: longitudinal findings from ITC Surveys in five countries
BV Fix, RJ O'Connor, N Benowitz… - Nicotine & tobacco …, 2017 - academic.oup.com
Introduction The ratio of trans 3'-hydroxycotinine (3HC) to cotinine (nicotine metabolite ratio
[NMR]) is a biomarker of the rate of nicotine metabolism, with higher NMR indicating faster …
[NMR]) is a biomarker of the rate of nicotine metabolism, with higher NMR indicating faster …
Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers
MJ Chenoweth, M Novalen, LW Hawk Jr… - … Biomarkers & Prevention, 2014 - AACR
Background: The ratio of 3′ hydroxycotinine to cotinine, or nicotine metabolite ratio (NMR),
is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine …
is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine …
The use of the nicotine metabolite ratio as a biomarker to personalize smoking cessation treatment: current evidence and future directions
The nicotine metabolite ratio (NMR), a genetically informed biomarker of rate of nicotine
metabolism, has been validated as a tool to select the optimal treatment for individual …
metabolism, has been validated as a tool to select the optimal treatment for individual …
Stability of the nicotine metabolite ratio in smokers of progressively reduced nicotine content cigarettes
G St. Helen, P Jacob III… - Nicotine & tobacco …, 2013 - academic.oup.com
Introduction: The nicotine metabolite ratio (NMR), the ratio of trans-3′-hydroxycotinine (3-
HC) to cotinine, has been used as a biomarker of the rate of CYP2A6-mediated nicotine …
HC) to cotinine, has been used as a biomarker of the rate of CYP2A6-mediated nicotine …
Reproducibility of the nicotine metabolite ratio in cigarette smokers
G St. Helen, M Novalen, DF Heitjan, D Dempsey… - … , biomarkers & prevention, 2012 - AACR
Background: The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …
Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies
HK Giratallah, MJ Chenoweth, N Addo… - Drug and alcohol …, 2021 - Elsevier
Abstract Background Variation in CYP2A6 activity influences tobacco smoking behaviors
and smoking-related health outcomes. Plasma Nicotine Metabolite Ratio (NMR) is a robust …
and smoking-related health outcomes. Plasma Nicotine Metabolite Ratio (NMR) is a robust …
Relationships between the nicotine metabolite ratio and a panel of exposure and effect biomarkers: findings from two studies of US commercial cigarette smokers
DM Carroll, SE Murphy, NL Benowitz, AA Strasser… - … Biomarkers & Prevention, 2020 - AACR
Background: We examined the nicotine metabolite ratio's (NMR) relationship with smoking
intensity, nicotine dependence, and a broad array of biomarkers of exposure and biological …
intensity, nicotine dependence, and a broad array of biomarkers of exposure and biological …
Associations between nicotine metabolite ratio and gender with transitions in cigarette smoking status and e-cigarette use: findings across waves 1 and 2 of the …
TL Verplaetse, MKR Peltier, W Roberts… - Nicotine and …, 2020 - academic.oup.com
Introduction Nicotine metabolite ratio (NMR), the ratio of trans 3′-hydroxycotinine to
cotinine, is a biomarker of nicotine metabolism. Discrepant findings among clinical trials and …
cotinine, is a biomarker of nicotine metabolism. Discrepant findings among clinical trials and …