Adeno-associated viral vectors in neuroscience research

DL Haggerty, GG Grecco, KC Reeves… - … Therapy-Methods & …, 2020 - cell.com
Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in
neuroscience research studies for interrogating cellular and neurocircuit functions and …

Adeno-associated virus toolkit to target diverse brain cells

RC Challis, S Ravindra Kumar, X Chen… - Annual review of …, 2022 - annualreviews.org
Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …

Viral strategies for targeting the central and peripheral nervous systems

CN Bedbrook, BE Deverman… - Annual review of …, 2018 - annualreviews.org
Recombinant viruses allow for targeted transgene expression in specific cell populations
throughout the nervous system. The adeno-associated virus (AAV) is among the most …

Biology of adeno-associated viral vectors in the central nervous system

G Murlidharan, RJ Samulski, A Asokan - Frontiers in molecular …, 2014 - frontiersin.org
Gene therapy is a promising approach for treating a spectrum of neurological and
neurodegenerative disorders by delivering corrective genes to the central nervous system …

Adeno-associated virus vectors and neurological gene therapy

DS Ojala, DP Amara, DV Schaffer - The Neuroscientist, 2015 - journals.sagepub.com
Gene therapy has strong potential for treating a variety of genetic disorders, as
demonstrated in recent clinical trials. There is unfortunately no scarcity of disease targets …

Gene therapy for neurological disorders: progress and prospects

BE Deverman, BM Ravina, KS Bankiewicz… - Nature Reviews Drug …, 2018 - nature.com
Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …

In vivo selection yields AAV-B1 capsid for central nervous system and muscle gene therapy

SR Choudhury, Z Fitzpatrick, AF Harris, SA Maitland… - Molecular Therapy, 2016 - cell.com
Adeno-associated viral (AAV) vectors have shown promise as a platform for gene therapy of
neurological disorders. Achieving global gene delivery to the central nervous system (CNS) …

Adeno-associated virus (AAV) vectors in the CNS

T J. McCown - Current gene therapy, 2011 - benthamdirect.com
Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this
vector system an excellent choice for both CNS gene therapy and basic neurobiological …

Adeno-associated virus vector for central nervous system gene therapy

D Zhu, AJ Schieferecke, PA Lopez… - Trends in Molecular …, 2021 - cell.com
The past several years have witnessed significant advances in the development of
therapeutic gene delivery for neurological disorders of the central nervous system (CNS). In …

Adeno-associated virus (AAV) vectors in the CNS

TJ McCown - Current gene therapy, 2005 - ingentaconnect.com
Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this
vector system an excellent choice for both CNS gene therapy and basic neurobiological …