Adeno-associated viral vectors in neuroscience research
DL Haggerty, GG Grecco, KC Reeves… - … Therapy-Methods & …, 2020 - cell.com
Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in
neuroscience research studies for interrogating cellular and neurocircuit functions and …
neuroscience research studies for interrogating cellular and neurocircuit functions and …
Adeno-associated virus toolkit to target diverse brain cells
RC Challis, S Ravindra Kumar, X Chen… - Annual review of …, 2022 - annualreviews.org
Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles
for neuroscience research. They have two engineerable features: the capsid (outer protein …
for neuroscience research. They have two engineerable features: the capsid (outer protein …
Viral strategies for targeting the central and peripheral nervous systems
CN Bedbrook, BE Deverman… - Annual review of …, 2018 - annualreviews.org
Recombinant viruses allow for targeted transgene expression in specific cell populations
throughout the nervous system. The adeno-associated virus (AAV) is among the most …
throughout the nervous system. The adeno-associated virus (AAV) is among the most …
Biology of adeno-associated viral vectors in the central nervous system
Gene therapy is a promising approach for treating a spectrum of neurological and
neurodegenerative disorders by delivering corrective genes to the central nervous system …
neurodegenerative disorders by delivering corrective genes to the central nervous system …
Adeno-associated virus vectors and neurological gene therapy
DS Ojala, DP Amara, DV Schaffer - The Neuroscientist, 2015 - journals.sagepub.com
Gene therapy has strong potential for treating a variety of genetic disorders, as
demonstrated in recent clinical trials. There is unfortunately no scarcity of disease targets …
demonstrated in recent clinical trials. There is unfortunately no scarcity of disease targets …
Gene therapy for neurological disorders: progress and prospects
Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …
In vivo selection yields AAV-B1 capsid for central nervous system and muscle gene therapy
SR Choudhury, Z Fitzpatrick, AF Harris, SA Maitland… - Molecular Therapy, 2016 - cell.com
Adeno-associated viral (AAV) vectors have shown promise as a platform for gene therapy of
neurological disorders. Achieving global gene delivery to the central nervous system (CNS) …
neurological disorders. Achieving global gene delivery to the central nervous system (CNS) …
Adeno-associated virus (AAV) vectors in the CNS
T J. McCown - Current gene therapy, 2011 - benthamdirect.com
Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this
vector system an excellent choice for both CNS gene therapy and basic neurobiological …
vector system an excellent choice for both CNS gene therapy and basic neurobiological …
Adeno-associated virus vector for central nervous system gene therapy
D Zhu, AJ Schieferecke, PA Lopez… - Trends in Molecular …, 2021 - cell.com
The past several years have witnessed significant advances in the development of
therapeutic gene delivery for neurological disorders of the central nervous system (CNS). In …
therapeutic gene delivery for neurological disorders of the central nervous system (CNS). In …
Adeno-associated virus (AAV) vectors in the CNS
TJ McCown - Current gene therapy, 2005 - ingentaconnect.com
Adeno-associated virus (AAV) vectors exhibit a number of properties that have made this
vector system an excellent choice for both CNS gene therapy and basic neurobiological …
vector system an excellent choice for both CNS gene therapy and basic neurobiological …