The redox regulator NRF2 becomes activated upon oxidative and electrophilic stress and
orchestrates a response program associated with redox regulation, metabolism, tumor …

Nrf2: INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to
link Nrf2 to the ubiquitin ligase Cul3–Rbx1 complex that ubiquitinate and degrade Nrf2 …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Metazoans viability depends on their ability to regulate metabolic processes and also to
respond to harmful challenges by mounting anti‐stress responses; these adaptations were …

Aging is the dominant risk factor for most chronic diseases. Development of antiaging
interventions offers the promise of preventing many such illnesses simultaneously. Cellular …

The transcription factor NRF2 coordinates the expression of a vast array of cytoprotective
and metabolic genes in response to various stress inputs to restore cellular homeostasis …

Simple Summary The stress-responsive transcription factor NRF2 (nuclear factor-erythroid 2
p45-related factor 2) directs cellular metabolic processes that can have diverse effects in the …

Endoplasmic reticulum (ER) stress generates reactive oxygen species (ROS) that induce
apoptosis if left unabated. To limit oxidative insults, the ER stress PKR-like endoplasmic …

ABSTRACT Activating Transcription Factor 3 (ATF3), a member of the ATF/CREB family, is
induced rapidly by various stresses. Its induction mechanism and role in response to …

INrf2: Nrf2 are sensors of chemical/radiation stress. Nrf2 dissociates from INrf2 in response
to a stress and translocates in the nucleus. This leads to induction of a battery of antioxidant …